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Forrer GR, Goldner RD. 
“Experimental physiological studies with lysergic acid diethylamide (LSD-25).”. 
Arch. Neurol.. 1951 May;65:581.
Studies with lysergic acid diethylamide (LSD-25) have been carried out in an effort to clarify the physiological and psychic responses attendant on administration of this drug in schizophrenic patients. The drug produced slight increase blood pressure, slight increase in pulse rate, no essential change in respiration; increase in salivation and lacrimation, dilation of the pupils, increase in deep reflexes and slight ataxia. Oral administration produced pupillary dilation of marked degree whereas topical administration produced very slight dilation. The total white blood cell count was increased during the time of action of the drug. Euphoria occurring in outbursts, was prominent. Increased accessibility and amiability, with increased release of libido and greater accessibility of delusional material, was observed. Visual hallucinations of the so-called primary type were not noted in two blind patients treated with the drug but were seen in all of the six patients on whom complete studies were carried out. Urinary constituents, the non-protein nitrogen level, the electroencephalogram, cephalin-cholesterol flocculation, weight and temperature were not affected by the administration of this drug in doses up to 6 micrograms per kilogram. Lysergic acid diethylamide appears to be a suitable substance for further therapeutic investigation in the psychoses.
Notes # : American
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