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Hameroff S, Trakas M, Duffield C, Annabi E, Gerace MB, Boyle P, Lucas A, Amos Q, Buadu A, Badal JJ. 
“Transcranial ultrasound (TUS) effects on mental states: a pilot study”. 
Brain Stimul. 2013 May 13;6(3):409-15.
Abstract
Transcranial ultrasound (TUS) can modulate brain function. To assess possible TUS modulation of mental states, we investigated effects on subjective reports of pain and mood of sub-thermal TUS versus placebo applied to frontal scalp and brain of chronic pain patient volunteers.



METHODS:

With IRB approval and informed consent, subjects with chronic pain completed two visual analog scales for pain (NRS) and mood (VAMS/Global Affect), and their vital signs were recorded 10 min prior to, and 10 min and 40 min following exposure to either subthermal TUS (8 MHz) or placebo (in a double blind crossover study) using the 12L-RS probe of a LOGIQe ultrasound imaging machine (General Electric, USA). A physician, also blinded for TUS versus placebo, applied the probe (with gel) to scalp over posterior frontal cortex, contralateral to maximal pain, for 15 seconds. A second investigator operated the ultrasound machine, randomizing TUS versus placebo. The process was then repeated, applying the opposite modality (TUS or placebo).

RESULTS:

Subjective reports of Mood/Global Affect were improved 10 min (P = 0.03) and 40 min (P = 0.04) following TUS compared with placebo. NRS pain reports slightly improved following TUS (P = 0.07) at 40 min.

CONCLUSIONS:

We found improvement in subjective mood 10 min and 40 min after TUS compared to placebo. TUS can have safe neurophysiological effects on brain function, and is a promising noninvasive therapy for modulating conscious and unconscious mental states and disorders. We suggest TUS acts via intra-neuronal microtubules, which apparently resonate in TUS megahertz range.
Comments and Responses to this Article
#
earth
Jul 8, 2017 0:00
DoesntCauseBrainDamage..WhatDoestheWordDamageMeanAgain #

The reference list is also disturbing and interesting. Did not show brain damage in a couple small mammal tests.. no "structural" changes or too much heat.

In my field, "brain damage" is defined with somewhat more attention to many types of more subtle permanent changes, like receptor bindings, receptor numbers, distribution of ligands, transfer, activity, etc.

I think I'll pass on this and let a generation or two of people play with that before we apply that to my skull.
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