Material Safety Data Sheets
The Vermont SIRI - Material Safety Data Sheet Collection
Iowa State University - Dept of Chemistry MSDS Collection
Psychoactive LD50sLD50 - The dose that has been determined to be lethal to 50% of the test population.
|LD50s for Various Substances|
|(with ratios regarding relative safety/toxicity)|
|Alcohol (Ethyl)||10.6 g/kg||o||young rats|
|7.06 g/kg||o||old rats|
|Caffeine||127 mg/Kg||o||mice (male)||100-200 mg o|
|137 mg/Kg||o||mice (female)|
|DET||28 mg/kg||iv||mouse||60 mg im/po|
|DIPT||26 mg/kg||iv||mouse||30 mg o|
|DMT||110 mg/kg||im||mouse||60 mg im|
|5-MeO-DMT||115 mg/kg||ip||mouse||6 mg p|
|DPT||20 mg/kg||iv||mouse||60 mg po|
|Sodium-GHB||2,000 mg/kg||ip||male rats|
|1,650 mg/kg||ip||female rats|
|Ibogaine||82 mg/kg2||ip||guinea pig|
|400 mg / kg||ip||mouse|
|LSD||46 mg/Kg||iv||mice||0.25 mg o|
|9.5 mg/Kg||ip||mice||.7 mg(smoked)|
|Psilocybin||285 mg/Kg||iv||mice||12-20 mg o|
|THC||1270 mg/Kg||o||rats(male)||20 mg o|
|730 mg/Kg||o||rats(female)||20 mg o|
|105.7 mg/Kg||iv||rats||5 mg(smoked)|
|42 mg/Kg||(inhalation)||rats||5 mg(smoked)|
|Aspirin||1100 mg/Kg||o||mice||325 mg o|
|Acetaminophen/paracetamol||338 mg/Kg||o||mice||500 mg o|
|Vitamin A||2570 mg/Kg||o||mice||10-20 mg o|
|Succinyl Choline||.45 mg/Kg||iv|
|VX (nerve gas)||.0154 mg/Kg||iv||rabbits||0 mg|
iv = intravenous (injected into vein)
ip = intraperitoneal (injected into body cavity)
im = intramuscular (injected into muscles)
o=oral (swallowed or eaten)
p=parenteral (not by mouth / usually means 'inhaled' or 'snorted')
mg/Kg = milligrams of drug per Kilogram of body weight
mg = milligrams of drug
Example acute oral LD50s (rat): Example LD50 (mg/kg) Citric acid (solid) 3,000 10% Citric acid Soln. 30,000 Acetone 5,800 Benzoic acid 1,700 Caffeine 192
NOTES:The "LD50" is the dose of a substance that will kill a selected species of experimental animal 50% of the time.
All LD50's are normalized to milligrams/Kilogram of animal's body weight.
"Typical Human Dose" info is taken from various sources, including "Burger's Medicinal Chemistry", "Journal of Psychedelic Drugs", "The Merck Manual", "NIOSH Registry of Toxic Effects of Chemical Substances", cigarette packages, No-Doz bottles, etc.
One might well argue that it is of questionable utility to compare toxic responses between various species using different routes of administration. Needless to say, many rodents have died for our sins.
It was later pointed out that what is called above a "safety ratio" is roughly equivalent to the pharmacological measure known as the "Therapeutic Index". The therapeutic index is a measure of the toxicity of a drug relative to it's usual therapeutic dose.
The NIOSH Registry of Toxic Effects of Chemical Substances also lists most published LD50 measurements, but does so uncritically. It's quite useful as a point of reference.
- Unless otherwise marked, all LD50 data were found in the "The Merck Index, 11th edition".
- Goutarel R, Gollnhofer O, Sillans R. "Pharmacodynamics and Therapeutic Applications of Iboga and Ibogaine." Psychedelic Monographs and Essays #6. Ed. Thomas Little.
Pompano Beach: PM & E Publishing Group, 1993. 70-111.
- Toxicol. Appl. Pharmacol. 4, 547 (1962)
- Bedford JA, Turner CE, Elsohly HN. "Comparative lethality of coca and cocaine." Pharmacol Biochem Behav 1982 Nov; 17(5):1087-8
- U.S. Dept of Justice - DEA. MDMA Scheduling Hearings with Francis L. Young, Administrative Law Judge. [full text].