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Salvia divinorum Extractions
Method 1 - Isopropanol or Reagent Grade Acetone
Method 2 - Denatured Alcohol

Salvia divinorum - Extraction - Method 1

Either Isopropanol or reagent grade acetone:

  1. Put leaves in glass beaker with reagent grade acetone for 3 days.
    * Note the solvent turns green and leaf becomes paler.
  2. Strain leaves out of acetone, pouring acetone into glass double boiler / beaker in hot waterbath.
  3. Reserve spent leaves.
  4. Boil acetone to evaporate as much solvent as possible.
  5. Add small amount of spent salvia leaves to oily residue and stir leaves to remove residue from glass.
  6. Remove leaf
  7. Add more acetone to beaker/double boiler to redisolve oily residue clinging to glass.
  8. Repeat evaporation procedure.
  9. Add spent leaves to another volume of acetone and repeat steps 1-8 above.
Using 1 ounce dried salvia leaf and ~100 ml acetone, the yield was 2gm final dry 'super salvia'... This product should be used carefully, perhaps with a sitter because it is strongly entheogenic.

Salvia divinorum - Extraction - Method 2

Denatured Alcohol :

  1. Take approximately 30 dried leaves and crush them by hand.
  2. Put them in a mason jar soaking in 1/2 cup of denatured alcohol.
  3. Let soak for 2 hours.
  4. Decant (pour off) the alcohol into a small non-aluminum dish.
  5. Add about 5 dried crushed leaves.
  6. Set a fan to blow over the dish to speed the evaporation process.
  7. Preheat oven to 250 degrees F.
  8. Turn oven off and place dish inside the oven while it's still hot.
  9. The small amount of water absorbed by the alcohol should dry within about 15 minutes.
  10. Scrape all material from the dish with a razor blade (that's why you're not using an aluminum dish).
  11. Smoke with care.
In this method, the denatured alcohol (pure ethanol with a small amount of methanol added) seems a good alternative solvent to acetone as Valdez reported using aqueous methanol as a polar solvent to extract nonpolar hexane extracts, increasing the concentrations of salvinorin-a before using chromotographic separation to obtain the purified compound.