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Caution :   Reactions and experiences may vary dramatically from person to person. [see below]
Peyote Duration
Total Duration
5 - 8 hrs
60 - 120 mins
Coming Up
30 - 60 mins
3 - 5 hrs
Coming Down
1 - 2 hrs
After Effects
6 - 8 hrs
Hangover / Day After
- - -
  • feelings of insight
  • brightening of colors
  • closed and open eye visuals
  • mood lift, euphoria1
  • increased giggling and laughing
  • increase in energy (stimulation)
  • increased tactile sensation
  • happy, dreamy feelings1
  • feelings of hope or rejuvination1
  • increased access to spiritual ideation; deep esoteric experiences1
  • general change in consciousness (as with most psychoactives)
  • loss of appetite
  • change in body temperature regulation
  • unusual thoughts and speech
  • unusual focus on either small details or large concepts; changes in meaning or significance of experiences1
  • mild to extreme distractability1
  • changes in perception of time1
  • changes in perception of "reality"
  • changes in self control1
  • unusual body sensations (facial flushing, chills, goosebumps, body energy)
  • ego softening
  • pupil dilation1
  • body tremors1
  • urge to urinate1 (in early stages of experience)
  • restlessness
    (likelihood of negative side effects increases with higher doses)
  • nausea and/or vomiting
  • chest and neck pain1 (in early stages of experience)
  • shortness of breath1
  • uncomfortable changes in body temperature (sweating/chills)
  • confusion, difficulty concentrating, problems with activities requiring linear focus
  • difficulty communicating1
  • inhibition of sex drive
  • insomnia
  • unpleasant or frightening visions
  • unwanted and overwhelming feelings, depression, anxiety
  • paranoia, fear, and panic
As with many other psychedelics, the coming-up period of a peyote experience can be uncomfortable with some of the more negative effects occurring during this time.

Erowid's effects information is a summary of data gathered from users, research, and other resources. This information is intended to describe the range of effects people report experiencing. Effects may vary dramatically from one person to another or one experience to another based on a variety of factors such as body chemistry, age, gender, physical health, dose, form of material, etc.