#51. PRO-LAD6-NORLYSERGIC ACID, N,N-DIETHYLAMIDE 6-PROPYL; 6-NORLYSERGAMIDE, N,N-DIETHYL-6-PROPYL; N,N-DIETHYLNORLYSERGAMIDE, 6-PROPYL; 6-PROPYLNORLYSERGIC ACID, N,N-DIETHYLAMIDE; 9,10-DIDEHYDRO-6-PROPYL-N,N-DIETHYLERGOLINE-8b-CARBOXAMIDE; 6-PROPYL-NOR-LSD
|[3D .mol structure]|
DOSAGE : 100 - 200 micrograms, orally
DURATION : 6 - 8 hrs
QUALITATIVE COMMENTS : (with 80 µg, orally) "I am aware of some change within a quarter hour, and then nothing more for quite a while. Certainly no visuals, almost like MDMA in that I am not really sure that this is even psychedelic -- it does not have any of the flavor of LSD. I want to try it at a higher dose some day."
(with 135 µg, orally) "A strange development into a sort of paranoia place, without any reasonable dialog with my partner. A light-headed experience of a different kind, but we did not find common space. Not too comfortable -- emotions are dull. At about mid-experience, considerable visuals came into play, with easy fantasy interlocking with music. Brüchner's viola quintette in A produced extraordinary castle frames within castle walls. Emotions were reknit, food was good, and sleep fine at the 8th or 9th hour. It is not up to LSD (if that is your standard) because it is basically not like LSD."
(with 175 µg, orally) "This is an intellectually clear material, but it is a funny material. I am certainly at a +++ or at least I was a couple of hours ago. How does one describe PRO-LAD? It's not-quite-this and not-quite-that sort of stuff. Or, to borrow from Winnie-the-Pooh, 'It's not at the bottom, and it's not at the top (but this is the stair where I always stop)' -- oh, never mind. I mean, I'm not sure how to categorize this material. It's pleasant, it's fine for fooling around, it's good for humor, even excellent. It's very good for clear thinking, although not cosmic-type particularly. It's a sort of nice, comfortable, middle-American, July-Fourth-Picnic, apple-pie with ice cream sort of psychedelic, the kind that you can wrap up in gold and white striped paper for your youngest aunt, the one who likes to think she's really a bit wild, you know -- the kind of psychedelic that's a bit much for your Dad or Mom, but it's just jazzy enough to keep some younger relatives happy with you for a few months. However, I must tell you, kid, if you try to bring this to the Big Town, well... It is pretty much dropped off, now. Ah'm gonna lie mahself on down."
EXTENSIONS AND COMMENTARY : With success in the preparation of the rather stable nor-LSD intermediate, any number of 6-substituted nor-LSD homologues and analogues can be synthesized. Simply use the appropriate alkyl bromide or alkyl iodide and the desired product will be in hand, after a modest amount of rather sophisticated purification at a micro scale. Several analogues are in the chemical literature, and some of them have been explored in direct comparison to LSD. Here are a few examples:
N-Propynyl-nor-LSD (PARGY-LAD). Some activity at 160 µg. Active at 500 µg.
N-Butyl-nor-LSD (BU-LAD). Something at 500 µg.
N-Phenethyl-nor-LSD (PHENETH-LAD). Nothing at 500 µg.
As these substituents get heavier and heavier, the potency of the products drop by an order of magnitude or so, or even more. But here, in this N-substituted nor-LSD family, there is a fantastic research opportunity just waiting to be exploited, an exact parallel to the radio-iodine labeling of DOI as was described in PIHKAL. It is a good guess that this position is one of good metabolic stability. So what about putting on a small group that can be labeled with a reasonably long-lived positron isotope? A specific proposal: N-(2-fluoroethyl)-nor-LSD with an 18-F radio-label. The compound should be makable rather quickly (nor-LSD and 18FCH2CH2I in DMF with potassium carbonate) and cleanly purified by centrifugal chromatography, all well within the almost two hour half-life considerations of radio-fluorine. Here is a group that would be (in theory) intrinsic to the central activity of the end product, N-(2-fluoroethyl)-nor-LSD. The end compound could be synthesized, purified, characterized and sterilized quickly, allowing its brain localization and central dynamics to be determined by PET scanning, with virtually no risk to the subject. Let's call it FLUORETH-LAD.
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