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#59 DMMDA-2


[3D .mol structure]
DOSAGE: about 50 mg.

DURATION: unknown.

QUALITATIVE COMMENTS: (with 50 mg) I am into it; it is much like MDA.

EXTENSIONS AND COMMENTARY: This is pretty sparse information upon which to build a picture of biological activity. First, the synthesis was done by someone else and, as I have not been able to find where the notes are, this will be the one recipe in the footnote without explicit directions incorporated. The procedure used was exactly the same as that described for DMMDA, except that the starting material was dillapiole rather than apiole. The dillapiole was obtained by the careful fractionation of Oil of Dill (as opposed to the isolation of apiole from the careful fractionation of Oil of Parsley). Isomerization to isodillapiole, nitration with tetra-nitromethane to give 1-(2,3-dimethoxy-4,5-methylenedioxyphenyl)-2-nitropropene, and its reduction with LAH in ether to give 2,3-dimethoxy-4,5-methylenedioxyamphetamine hydrochloride (DMMDA-2) proceeded in a precisely analogous manner to the preparation of DMMDA.

And the pharmacological part is rather thin as well. I was not the taster, and can only quote what I had been given. This same observer found a threshold at 28 milligrams. Under other circumstances, this comment on DMMDA-2 would have been tucked into the commentary on DMMDA where it belongs, but the activity level was called for in a large review article, and on the basis of the above, both its initials and the value of 5x the potency of mescaline were permanently enshrined in the published literature. What is it really like? I don't know. Its structure is an appealing amalgamation of that of MMDA and MMDA-2, and it might be quite a winner if the dosage and the duration were known. It is, after all, one of the ten essential amphetamines, since dillapiole is one of the ten essential oils.

At the time that DMMDA and DMMDA-2 were synthesized, I had visions of doing the same thorough study with these as I had set up with the TMA's (six possible, six done) and the MMDA's (six possible, five done). Here, too, with a pair of methoxy groups on an amphetamine skeleton, with a methylenedioxy ring thrown in, six isomers are possible but only these two have been prepared. The unknown ones will certainly be called DMMDA-3, -4, -5 and -6, but the assignments of code to structure haven't even been thought out yet. The remarkable and totally unexpected activity of DOM was discovered at about this time and it was a much more tempting direction to follow. The remaining four possible DMMDA's have been left to that famous time, a future Rrainy day.

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