Citation: Euslace Nodd. "Can't Remember What It Was Like to Feel Depressed: An Experience with Buprenorphine / Naloxone (Suboxone) (exp91263)". Erowid.org. Jun 5, 2019. erowid.org/exp/91263
Buprenorphine for Depression
I had what they call treatment-refractory depression. It means that all the regular medications didn't work. I've tried at least five different ones, including Cymbalta, Wellbutrin, Symbyax, Concerta, and Prozac. Not a single one of these did anything for me and most made me feel HORRIBLE. So I started self-medicating. Opioids were the ONLY thing that made me feel normal, but there are obviously a lot of drawbacks to the mu-agonists.
Opioids were the ONLY thing that made me feel normal, but there are obviously a lot of drawbacks to the mu-agonists.
Eventually those drawbacks led me to an internist who prescribed Suboxone (buprenorphine/naloxone). It makes me feel just GOOD, but not like like an amphetamine or a cocaine good, just pleasant and positive, happy and calm. I have to stress, it is NOTHING at all like the amphetamines, its much more subtle.
I'm down to 8 mg/day now, and I can't remember what it was like to feel depressed. I've read that doses can go as low as 1 to 0.5 mg and still be effective for depression. I used to get a slight high from it, but my tolerance is up now and I just feel normal.
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