The Forgotten Opioid
Citation:   The Monkey Mantra. "The Forgotten Opioid: An Experience with Loperamide (exp65176)". Feb 6, 2008.

86 mg oral Loperamide (pill / tablet)
I'm sitting in the Burlington International Airport in Vermont, waiting for my delayed flight home to the Bay Area. I've just finished a weird two week vacation with my boyfriend that included a few trials with high-dose imodium. Half-way through the vacation my grandpa called to let me know he would be entering hospice care and would be dying shortly. Like any good grandkid I packed my stuff up and flew out of Vermont the next morning to see him. I stopped by a drug store that night to pick up 96 pills of immodium to use on the flight back. My back had been killing me and I figured hey, loperamide can't cross the blood brain barrier, but that just means not MUCH of it can cross, right? Either way, I'd read a couple abstracts showing high-dose loperamide can provide peripheral analgesia. There's also a good bit of anecdotal evidence it can ease opioid withdrawal, so I figured it'd be worth a shot as a booster on the ibuprofen and alcohol.

Curiosity had me trying like 25 pills that night and another 30 or so the next day. Effects took a couple hours to kick in, but things started to get icky tummy-wise after like 30 minutes. Whodathunk? Anyway, the effects weren't super noticeable at first. When I redosed with 30 for the flight back to vermont the next evening, I started to get a feel for the nature of the stuff. Here's a bullet-point list of the effects:

* Weird opioid feeling in the eyes - droopy
* Weird opioid tummy feeling, like the one that hits on the comedown
* Weird opioid throat scratchiness and voice change
* A strange opioid feeling of dopey drowsiness that never quite becomes euphoric
* A possible analgesic effect
* Oversleeping like 12 hours when I normally sleep like 7
* Sex? Forget it.

I didn't shit for three days. When I did finally get a bowel movement it smelled like it'd been hanging around my colon since the time of the pharaohs.

I dosed the remaining 43 pills on the way back to the west coast. Again, major tummy ache which dissipated after an hour or two. Again, all the strange 'side-effects' of opioids without any real euphoria. I *do* feel like I could sleep better once I get on the plane. I'm relaxed, physically. I think I'll have a glass of wine on the plane and then I'll sleep through my red-eye flight home.

Overall verdict? If this stuff works for people going through withdrawal, I'm stoked for them. For those just trying to catch a buzz, man, look *elsewhere*.

One more point: DURATION! Lasts for like 2 days. Makes sense given its close relation to methadone.

The Monkey Mantra

Exp Year: 2007ExpID: 65176
Gender: Male 
Age at time of experience: Not Given
Published: Feb 6, 2008Views: 31,970
[ View PDF (to print) ] [ View LaTeX (for geeks) ] [ Swap Dark/Light ]
Loperamide (459) : Various (28), General (1)

COPYRIGHTS: All reports copyright Erowid.
No AI Training use allowed without written permission.
TERMS OF USE: By accessing this page, you agree not to download, analyze, distill, reuse, digest, or feed into any AI-type system the report data without first contacting Erowid Center and receiving written permission.

Experience Reports are the writings and opinions of the authors who submit them. Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.

Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults