Citation: Dale. "Pain Relief Not Up To Expectations: An Experience with Meperidine & Promethazine (Meprozine) (exp63331)". Erowid.org. Dec 30, 2015. erowid.org/exp/63331
In the middle of May, 2007, I had lower-back surgery (discectomy) and I was given Vicodin and Percocet for pain. A few days later, I contacted the doctor who conducted my surgery to report that the medication I was taking for post-operative pain wasn't helping. He wrote me for a medication called: Meprozine 50/25. This is a combination of Demerol/Meperidine(synthetic Opiate Analgesic) and Promethazine (anti-nausea).
Anyway, I started off taking the recommended dosage of 100mg (2x 50mg capsules). Realizing it wasn't even as strong as the other medication I was already taking, I decided that I'd up the dose at the next time I was due to take my medications. I popped four capsules (200mg) to see if I could actually feel better. Here is a timeline of this medication's affect at high levels:
15 Minutes After Oral Administration - Not too much that I can tell at the moment. Still in a lot of pain and I don't notice any euphoria.
25 Minutes After Oral Administration - I'm definitely feeling impaired. I'm experiencing a euphoric sensation. It's rather powerful but is accompanied by a slight dizziness and disorientation. I'm still awake and alive, able to see and hear everything appropriately. No hallucinations, either audible or visual.
45 Minutes After Oral Administration - It's gotta be either peaking by now or damn close. i have a tremendous head-buzz but it's not unenjoyable. It's like the euphoria and the head-buzz are the same thing, just very enhanced. My pain seems to be controlled somewhat which is definitely the best out of anything else I could be feeling.
1 Hour After Oral Administration - Feels like I'm coming down a bit. The head-buzz has almost disappeared and the back pain is picking up in intensity. Still enjoying some decent euphoria.
1 Hour, 30 Minutes After Oral Administration - I'm pretty sure that's about it. I'm not feeling anything other then pain. No head-buzz or euphoria. No headache or hangover feeling. Just back to what I was before I popped the medication.
In closing, this medication doesn't seem like something a doctor/surgeon should prescribe for someone straight out of surgery or for severe pain. I will probably never take it again. I'm not at all satisfied with anything it has to offer. Not sure why it was prescribed over hydrocodone and oxycodone.
Anyway, that's it.
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