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Busting the Blockade
Naltrexone, Heroin, Alprazolam & Zolpidem
Citation:   quackntrash. "Busting the Blockade: An Experience with Naltrexone, Heroin, Alprazolam & Zolpidem (exp54901)". Erowid.org. Jul 6, 2007. erowid.org/exp/54901

T+ 0:00
25 mg oral Naltrexone (pill / tablet)
  T+ 1:00 3.0 mg oral Pharms - Alprazolam (pill / tablet)
  T+ 3:00   IM Heroin  
  T+ 3:30 12.5 mg oral Pharms - Zolpidem (pill / tablet)
  T+ 13:00   IM Heroin  
A little background:
For the past 2 years I have been addicted to vaious opiates, namely heroin. Recently, my parents forced me into a buprenorphine (Subutex) detox program. Over the course of three weeks I tapered from 16mg or bup to 2mg. According to my doctor I was to wait ten days and then begin a daily 50mg dose of naltrexone (a potent opioid antagonist, aka. blocker).

My experience:
T 0:00 It had been eight days since my last bup dose and in order to leave my house my parents required me to begin the naltrexone. I felt it had been long enough and took half a pill to test it out.

T 0:30 I felt fairly normal and left home for a friends house.

T 0:45 I began to sweat. It didn't suprise me because I usually sweat a little.

T 1:00 I arrived at my friends house and was feeling a bit edgy like the beginning of opiate withdrawal. My buddy offered me three 1mg xanax pills which I swallowed immediately. These had no noticeable effect.

T 1:30 My entire body was sweating and my stomach was killing me. I believe the discomfort was more from the naltrexone itself and not opiate withdrawal. Opiate withdrawal is much more intense.

T 2:00 After talking with my friends for a bit I was feeling too uncomfortable to stay any longer and left for home.

T 3:00 Once I got home and tried to rest awhile I remembered that I could overpower the naltrexone by administering large amounts of opiates. Well, I gave that little thought before injecting 2 bags (approx. 60mg) of heroin intramuscularly.

T 3:30 All of the uncomfortable physical symptoms have subsided. I am not high, but feel back to baseline. I know that I will not be able to sleep one my own and therefore take an Ambien CR. This put me to sleep.

T 12:00 Upon waking I feel rested without the usual grogginess associated with Ambien.

T 13:00 I decided to test the effectiveness of the so called naltrexone blockade by injecting another three bags (90mg) of heroin. This puts me at ease and I feel slightly high. If I were to inject another two bags I'm sure I would get that warm comforting hug that only heroin can give me.

Conclusion: It is possible to overcome the blockade produced by naltrexone. However, all sources I have consulted advise strongly against it. Several weeks prior I injected two bags (60 mg) of heroin and got very very high. This leads me to believe that the seven bags I used over the course of this experience would have killed me if not for the naltrexone. I am sceduled to receive a Vivitrol (380mg, 1 month time release naltrexone) shot in a few days. I will not try this same experiment with the shot as I'm sure it would take a massive dose of heroin and would probably kill me.

Exp Year: 2006ExpID: 54901
Gender: Male 
Age at time of experience: Not Given
Published: Jul 6, 2007Views: 28,531
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Naltrexone (338), Heroin (27) : Addiction & Habituation (10), Combinations (3), Various (28)

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