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LSD, Sertraline & Bupropion
by Rapkarla
Citation:   Rapkarla. "Disappointment: An Experience with LSD, Sertraline & Bupropion (exp54624)". Erowid.org. Jun 14, 2007. erowid.org/exp/54624

T+ 0:00
200 mg oral Pharms - Sertraline (daily)
  T+ 0:00 300 mg oral Pharms - Bupropion (daily)
  T+ 0:00 1 hit oral LSD (blotter / tab)
  T+ 4:30 1 hit oral LSD (blotter / tab)


I take 200 mg sertraline and 300 mg bupropion daily for depression. I had read that anti-depressants can lessen the effects of psychedelics such as LSD. I figured that a little trip is better than no trip at all, right?

I took just one tab at first, because I am sensitive in general to psychoactive substances. I was with a very experienced psychonaut friend, R, just hanging out in my apartment. I was a bit nervous because I've landed in the ER with bad drug interactions before and it sucks. But I felt pretty confident that my day wouldn't end in a hospital. R and I watched tv while I waited to feel something. I did feel pretty weird. It felt a little like the body high from a low dose of DXM, with almost none of the mental/emotional intrigue. My neck got very stiff and sore, and I couldn't focus my eyes properly. I had no visual or auditory hallucinations of any kind. The most noticeable aspect was a kind of buzzing feeling in my whole body, like it was antsy and ready to blast off to outer space but couldn't quite make it off the ground. I took a second tab about 4-5 hours after the first one just to see if it was a matter of dosage. It wasn't.

One thing that was mildly interesting: I couldn't taste food. My brain was receiving the information all the same, but I was experiencing it in a way other than tasting, I don't know what exactly. I guess that's a kind of synesthesia, like hearing colors or whatever. I spent most of the 'trip' laying around watching tv and trying to sleep off the neck and jaw stiffness. I couldn't sleep though. Overall a huge disappointment followed by a massive 24-hour headache. I will have to plan very carefully if I want to try to go off the meds for a few days so I can attempt to trip. It's not usually worth it.

Exp Year: 2006ExpID: 54624
Gender: Female 
Age at time of experience: Not Given 
Published: Jun 14, 2007Views: 15,301
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LSD (2), Pharms - Sertraline (88), Pharms - Bupropion (87) : Hangover / Days After (46), Combinations (3), Small Group (2-9) (17)

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