Blocked Some Effects, Others Unaffected
MDMA (Ecstasy) & Escitalopram (Lexapro)
by HP
Citation:   HP. "Blocked Some Effects, Others Unaffected: An Experience with MDMA (Ecstasy) & Escitalopram (Lexapro) (exp39637)". Erowid.org. Apr 21, 2010. erowid.org/exp/39637

 
DOSE:
10 mg oral Pharms - Escitalopram (daily)
  150 mg oral MDMA  
BODY WEIGHT: 70 kg
I'd like to describe the effects I experienced on MDMA after I had been taking the SSRI Escitalopram for over three weeks at 10mg a day for depression. I am an occasional MDMA user, and I had hoped this dose of MDMA would be sufficient despite the possible SSRI interaction. However I was disappointed to find the positive effects of MDMA were completely lacking, both physically (tactile and body sensations) and psychologically (euphoria and empathy). I actually felt a bit depressed, and quite lethargic, despite being in a party environment at the time. The only effects I recognised were general stimulant side effects, jaw tension/teeth grinding, difficulty sleeping etc. So I conclude, since the MDMA was reliable, that the Escitalopram effectively blocked the empathogenic / euphoriant effects of the MDMA whilst the stimulant properties remained more or less unaffected. I am curious to know whether the effects of hallucinogens such as LSD/psilocybin would also be reduced by such a degree.

Exp Year: 2005ExpID: 39637
Gender: Male 
Age at time of experience: Not Given
Published: Apr 21, 2010Views: 15,199
[ View PDF (to print) ] [ View LaTeX (for geeks) ] [ Swap Dark/Light ]
MDMA (3), Pharms - Escitalopram (304), SSRIs (396) : Combinations (3), Large Group (10+) (19)

COPYRIGHTS: All reports copyright Erowid.
No AI Training use allowed without written permission.
TERMS OF USE: By accessing this page, you agree not to download, analyze, distill, reuse, digest, or feed into any AI-type system the report data without first contacting Erowid Center and receiving written permission.

Experience Reports are the writings and opinions of the authors who submit them. Some of the activities described are dangerous and/or illegal and none are recommended by Erowid Center.


Experience Vaults Index Full List of Substances Search Submit Report User Settings About Main Psychoactive Vaults