Citation: Xerxes. "5-HTP Cannabis Preloading Double Blind Study: An Experience with 5-HTP & Cannabis (exp12676)". Erowid.org. Feb 10, 2003. erowid.org/exp/12676
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Upon hearing of a possible synergy between 5-HTP, a serotonin precursor, and marijuana, I obtained a bottle of the above mentioned suppliment from a local grocery store in the vitamin section.
100mg of 5-HTP was given to a friend, and he was instructed to put this substance in a 00 size gelcap. He then filled a second gelcap with sugar. He marked the gelcaps with a #1 and a #2, taking note of which number gelcap contained the 5-HTP.
A second friend recieved the gelcaps, and was not told which gelcap contained the 5-HTP. His job was to randomly administer to myself the gelcaps. I would swallow the pills with eyes closed, so as not to accidently distinguish between the appearance of the sugar and the 5-HTP however subtle.
3 sessions were to take place, each occouring 1 week after the previous. I abstained from all marijuana use for 1 week before beginning the study, and I haden't used any other drugs for at least 6 months, excluding nicotine and caffeine, which were present throughout the studies. The marijuana was in the form of 3 medium-small joints, all originating from the same bag. The buds were finely chopped, mixed, and weighed into 3 equal piles, and rolled.
The first joint was smoked. Nothing much to note, moderate quality marijuana, the usual effects. The Marijuana is definatly not laced with anything, and is the same as what I am used to.
(later determined to be the 5-HTP session)
0:00 - Gelcap ingested on empty stomach.
0:30 - No alteration is noticed from the gelcap. At this time the marijuana is smoked. I definatly feel different than with just the marijuana. Perhaps placebo, perhaps not.
0:35 - Now I'm sure I feel different. The high is faster, and more psycadelic compared to a normal marijuana high. I feel almost speedy, and euphoric. Very similar to some of my first pot experiences. If this is a sugar pill, I have to invest in some sugar.
1:00 - I still feel very 'up.' Interesting, the high has mellowed a little, but the main effects havent really declined that much.
3:00 - 3 hours into the experience, and I'm definatly near baseline. The duration of the high seems to not have been affected by the pill I took.
conclusion - I believe this was the 5-HTP session, but I could always be wrong. Marijuana was definatly enhanced by whatever was in that pill.
(later determined to be the placebo session)
0:00 - Gelcap ingested on an empty stomache.
0:30 - No alteration noticed from the gelcap. At this time the marijuana is smoked. I feel a little different than with just marijuana. Maybe I was wrong about the last session being 5-HTP.
0:35 - Now I feel just the regular marijuana high. Nothing really different. No speedy feeling, no euphoria other than the expected from pot, nothing.
1:00 - I'm convinced this is a placebo. I don't feel any different than with the control study.
3:00 - Near baseline
It seems that preloading with 5-HTP does have a marked and definate effect on the pharmacology of marijuana. The placebo and control sessions were nearly identical, while the 5-HTP session was marked by an enhanced high. The enhancement took the form of increased euphoria, more intense high, and speedier, less tired/sleepy, mental state. 5-HTP is readily available from vitamin and grocery stores, and is not extremely expensive. It provides a unique and interesting synergy with marijuana, and definatly warrants future exploration.
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