Fun Experience, Strange After Effects
MDMA, Bupropion & Oxcarbazepine
Citation:   dosei. "Fun Experience, Strange After Effects: An Experience with MDMA, Bupropion & Oxcarbazepine (exp117017)". Erowid.org. Feb 13, 2023. erowid.org/exp/117017

 
DOSE:
T+ 0:00
300 mg oral Pharms - Bupropion (daily)
  T+ 0:00 750 mg oral Oxcarbazepine (daily)
  T+ 0:00 2 glasses oral Alcohol - Beer/Wine  
  T+ 2:00   oral MDMA  
BODY WEIGHT: 180 lb
My partner and I like to do MDMA, usually only about 1-2x a year to avoid building any sort of tolerance.

I currently take prescription medications for bipolar disorder. Every morning I take 300mg buproprion (wellbutrin) and 300mg oxcarbazepine (trileptal), and at night I take 450mg oxcarbazepine.

I recall reading that other stimulants, such as adderall, can lessen the effects of MDMA, and have also heard that buproprion is chemically very similar to amphetamines. Because of this, I skipped my morning buproprion on the day that I planned to take it. The days before and after taking MDMA, I took my prescribed medications as usual.
I skipped my morning buproprion on the day that I planned to take it. The days before and after taking MDMA, I took my prescribed medications as usual.
I took both doses of oxcarbazepine as usual that day as well. I believe I did have a caffeinated soda that day, and at dinner about an hour before I had two glasses of wine.

We had acquired 1 gram of the drug in a crystal form, which we had never used before. Due to the irregular shape and size of each crystal, and lack of scale sensitive enough to weigh milligrams, I can't be sure how much either of us took. I swallowed one crystal, roughly spherical with a rough size of 1/16 inch in diameter. I am unable to know the weight, but visually an attempt was made to take a dose 1/5 of the 1 gram bag. [Erowid Note: Two samples of powder (even of the same chemical) with equivalent volumes won't necessarily weigh the same. For this reason, eyeballing is an inaccurate and potentially dangerous method of measuring, particularly for substances that are active in very small amounts. See this article on The Importance of Measured Doses.] a

The effects came on strongly and abruptly around 15-20 minutes after ingestion. Shortly thereafter I swallowed another, much smaller piece.

The feeling was very positive, I felt very giggly and silly. I felt full of love and admiration. Physical sensations in particular were amplified, which made sex, kissing, and cuddling all even more pleasant and satisfying than usual.

It is hard to gauge an accurate timeline after this. First ingestion was around 6:40pm, the effects kicked in around 7:00pm. It had a decently steep dropoff around 7:30, but I still felt very light and euphoric.

It was very difficult to eat food and I did not feel particularly hungry.

By around 10:30pm I was mostly just feeling alert. I had a feeling as though my brain was trying to feel a sense of dread, but physically couldn't. Throughout the night I slowly started to feel more normal. I tried to sleep but it was very difficult to settle down and couldn't stay asleep when I would finally fall asleep. I'm not entirely sure I ever fell fully asleep that night.

I woke up with my alarm around 9:30am the next day, but felt like I was partially awake for a while before that. Upon waking up I felt a bit tired and very dehydrated. I took an electrolyte drink and felt much better.

I did not notice any particular aftereffects that day, or the next day (Sunday).

However, I had some emotional nightmares Sunday and Monday night, and starting from when I woke up Monday I felt a very intense dread and depression, including thoughts of suicide and graphic intrusive thoughts. I also experienced an unusual paranoia. I do not think this is a common effect, and I initially did not think it was related, but I recalled that the previous time I had taken MDMA I had a moderate feeling of depression starting 1-2 days after ingestion.

The paranoia was particularly unusual to me. Due to the aforementioned bipolar disorder, I can occasionally experience a pseudopsychosis. This is typically where I may see things, or imagine or believe unusual or illogical reasons or stories behind things. I'm typically aware that this is happening, and can clearly identify that what I am seeing, hearing, or believing, is a product of my brain going a little haywire. The paranoia experienced was very strong, and of the variety of assuming I am being tracked or watched, and that others are plotting harm against me or are not who they say they are. This is not a type of paranoia that I would usually experience, and while I was still mostly aware that it was not real, it was much more severe than my usual experiences.

I also experienced a strong sense of general anxiety, including having an anxiety attack, which I also usually do not experience.

I haven't seen any report of this type of aftereffect or hangover, and imagine it is related to my condition. However, there was no other identifiable trigger, as I had been taking my medication as prescribed excluding the one missed dose of buproprion, which is generally not noticeable to miss a single dose. I was able to sleep well on Saturday and Sunday night, nightmares aside, and had not faced any great trauma or disruption in my life that could have triggered anything, nor did I experience anything where it would be logical and reasonable to have these fears.

The anxiety, depression, and paranoia primarily lasted through Monday and Tuesday. On Wednesday morning I woke up feeling grouchy and depressed, but after soaking up some sunlight I immediately felt much better, though still tired. The intrusive thoughts lasted through until Friday (one week from ingestion), but became less frequent and less severe and vivid throughout the week.

Despite this it was a positive experience. I wouldn't recommend doing this much or at all if one experiences bipolar disorder, schizophrenia, or anything of the like - though I think this is fairly common sense for most drugs.

Exp Year: 2023ExpID: 117017
Gender: Not Specified 
Age at time of experience: 26
Published: Feb 13, 2023Views: 366
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MDMA (3), Pharms - Bupropion (87), Oxcarbazepine (752) : Hangover / Days After (46), Combinations (3), Small Group (2-9) (17)

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