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A Valid Mild Painkiller With Caveats
MT-45 & Buprenorphone with Naloxine
Citation:   FlowGnome. "A Valid Mild Painkiller With Caveats: An Experience with MT-45 & Buprenorphone with Naloxine (exp109121)". Sep 9, 2016.

150 mg sublingual MT-45  
  1 mg sublingual Pharms - Buprenorphine (daily)
  250 ug sublingual Naloxone (daily)
I'll note from the start that at this point I'd been taking 1mg a day of suboxone for around 4 years. I was taking it at the time because I found it to be effective for both ADHD and depression, there wasn't much of anything recreational about it. I have left this off of many other reports because it was essentially my baseline at the time. There were no notable changes in effects of dissociatives or benzodiazepines at this level, and although it might be an important point of data to somebody it simply wasn't relevant to the effects of psychedelics; they had the same effects as always. Such is the nature of long-term use.

Previous tests with prescription opiates (hydrocodone, codeine) indicated that they required around 1.5x the normal dosage to have equivalent effects, there was not a full blockade at the 1mg level. Suboxone never functioned as much of a painkiller for me, and I was more interested in MT-45 as a possible replacement for those for mild-medium pain use that didn't justify the hassle of going to the doctor. I'd taken MT-45 a few times at increasing dosages starting at around 75mg before this and achieved some noticeable pain-relief effects at around 120mg, maybe equivalent to 10mg hydrocodone.

T+0:00 - Take 150mg MT-45 sublingually and go about my business, it takes a fairly large amount of time to kick in.

T+1:30 - Appears to have reached full level of effects. Mild pain relief is achieved at this dosage. The 'warm' body buzz of maybe 20mg of hydrocodone is apparent, but a dysphoric component is also noted along with some mild dissociation. Possibly kappa effects, it reminds me of larger dosages of buprenorphine. Not particularly recreational, but worth keeping around for pain relief if needed (which is what the rest of it was used for much later and well after I had stopped taking suboxone).

T+4:00 - Analgesic effects already wearing off. Not a particularly promising duration.
T+4:00 - Analgesic effects already wearing off. Not a particularly promising duration.
Slight dissociative component is still there and remains for another hour or two as the analgesic component / body buzz wear off.

Here I seem to have found another one that isn't particularly fun, but was still useful to have laying around later when I pulled a muscle. Later tests seemed to indicate that the buprenorphine had not caused much of a cross-tolerance or blockade of the effects of MT-45 for whatever reason, and I've not done enough research into its receptor affinities (if they've been published) to figure out why this was. Although plenty of other opioid agonists have appeared over the years, this one didn't seem to be quite as horribly dangerous as most of them at normal dosages / occasional use.

My verdict is that I'd restock for pain relief purposes (for mild pain) given the problem of getting a doctor to prescribe even the weakest pain reliever these days, but wouldn't bother keeping it around for much else.

Exp Year: 2014ExpID: 109121
Gender: Male 
Age at time of experience: 34
Published: Sep 9, 2016Views: 6,012
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Naloxone (339), Pharms - Buprenorphine (265) : Therapeutic Intent or Outcome (49), General (1), Alone (16)

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