From: firstname.lastname@example.org (Garbett, Shawn) Newsgroups: alt.drugs Subject: RE: PCP info sought possible FAQ beginnings Date: 6 Jan 1995 22:57 EST News-Software: VAX/VMS VNEWS 1.41 From several sources I've heard that PCP is making a reappearence on the drug scene. I have some excerts from _Clinical_Management_of_Poisoning_and_Drug_ Overdose by Haddad Winchester. A thourghly excellent reference, with very few errors, those errors that I have found (only one) is understandable due to lack of information at the time of printing. Chapter 33 Phencyclidine (PCP) written by Toby L. Litovitz, M.D. pg. 448-455 .. History of PCP as a anesthetic, but that it produced psychotic reactions in 15 to 20 percent of patients for 3 to 18 hours. Then a short history of its debut in San Francisco as PeaCe Pill and Hog. ... Now back to the text: In the early 1970s, phencyclidine reappeared on the streets, this time as a drug of deceit. Since it was easily and cheaply synthesized in clandestine "kitchen" laboratories without the risk of illegal importation, it was frequently substituted for and sold on the street as THC, cannabinol, mescaline, psilocybin, LSD, amphetamine, cocaine, Hawaiian woodrose, and other psychedelics. In fact, in one study only 3 per cent of analyzed street drug samples that contined PCP were actually sold as PCP. THC, which actually is not available on the street, was the most frequent misrepresenatation. .... More text on it's use through the 70s ... Considerable conflicting evidence exists in the literature regarding the mechanism of action of phencyclidine. Phencyclidine is thought to stimulate alpha-adrenergic receptors and to potentiate the pressor response to epinephrine, norepinephrine, and serotonin. Other studies have shown phencyclidine to have brief low level anticholinergic activity during the intial phase of intoxication. Phencyclidine is also thought to inhibit acetyl- and butyryl-cholinesterase. Others postulate that phencyclidine may act on opiate receptors. Phencyclidine abusers feel the onset of drug effect in 2 to 5 minutes when it is smoked, compared with 30 to 60 minutes when ingested orally. The peak effect is reached in 15 to 30 minutes after smoking the drug and abusers report that they stay "loaded" for 4 to 6 hours, then feel normal in 24 to 48 hours. ... PCC (1-piperidinocyclohexanecarbonitrile) appears in poorly synthesized batches as a by-product of the manufacturing process. When present in significant amounts (10 to 25 per cent), this contaminant causes abdominal cramps, bloody emesis, diarrhea, and coma. PCC is an unstable compound, degrading to piperidine. As a result, contaminated batches of PCP can sometimes be recognized by the strong fishy odor of piperidine. On heating (smoking), PCC liberates hydrogen cyanide, so the possibility of cyanide poisoning in PCP smokers should also be considered. .. Patients ingesting small amounts of phencyclidine present prominent body image distortions (enlarging limbs, detached head) on a background of sensory blockade described as a "numbness", depersonalization, "sheer nothingness" or "endless isolation". These patients feel inebriated, are usually disoriented, and sometimes have amnesia for the experience. Somatic sensation is dissociated: patients lose track of their bodies and are at risk of seriously injuring themselves because they do not perceive pain. Though visual, auditory, and tactile illusions and delusions (especially of being God, the devil, or an animal) are common, frank hallucinations are relatively uncommon when compared with those produced by LSD. Anxiety and, sometimes, outright hostility may be present. Disrobing in public is seen in a small percentage of patients. Perhaps the hallmark of PCP intoxication is the recurring delusion of superhuman strength and invulnerability resulting from the analgesic and dissociative properties of the drug. Intoxicated patients have been known to snap hancuffs and, unarmed, attack, large groups of people or police officers. This loss of fear has led patients to try to stop a train by standing in front of it, to grossly mutilate themselves and others, to climb into a polar bear's cave to take a picture, and to jump from windows or cliffs. The bizarre behavior is often violent, sometimes with gruesome mutilation of both the patient and his or her victim. One intoxicated abuser pulled out his front teeth with a pair of pliers. Another woman fried her baby in cooking oil. There are many reported assaults of friends and strangers, both with and without weapons. Many of these violent acts are committed by drug users who were previously totally nonviolent individuals. ... Note from Me: this is refering to moderate to high doses in the preceeding paragraph ... Patients with moderate or high dose intoxications are intially comatose. Those with moderate-dose intoxications have a relatively short duration of coma (several hours) compared with the prolonged coma associated with higher-dose exposures (usually lasting 6 hours to several days but occasionally persisting as long as 10 days). ... Much technical medical data deleted here ... Mildly intoxicated patients are best treated with sensory isolation in a nonthreatening environment on a cushioned surface in a darked, quiet room, without neglecting the need for frequent monitoring of vital signs. Instrumentation should be avoided. ... The techniques of "talking down" as advocated for most hallucinogens are ineffective for PCP and may instead further agitate patients. .. Medical data about higher doses and effective means of sedation ... ----- My notes follow Woah! Sounds damn bad. Highly not recommended, be careful this stuff is rarely sold for what it is. It is making another round right now. This is the kind of stuff that fuel prohibitionists, avoid it, tell others and spread the word. Print this out and distribute it. It is not just propaganda, the source of this information is highly reliable. Read it and believe it. Shawn .. ============================================================================= From: email@example.com (Garbett, Shawn) Newsgroups: alt.drugs Subject: PCP reading list Date: 9 Jan 1995 19:48 EST Message-ID: <9JAN199519484160@utkvx.utk.edu> Well here's the reading list and references for that paper on PCP that I posted excerts from by Toby L. Litovitz, M.D. Burns RS, Lernet SE: Causes of phencyclidine-related deaths. Clin Toxicol 12:463, 1978 Burns RS, Lerner SE: Perspectives: Acute phencyclidine intoxication. Clin Toxicol 9:477, 1976 Cogen RC, Rigg G, Simmons JL, Domino EF: Phencyclidine-associated acute rhabdomyolysis. Ann Intern Med 88:210, 1978. Ogelsby EW, Faber SJ, Faber SJ: Angel dust: What everyone should know about PCP. Lega-Books, Los Angeles, 1979. Rumack B: Phencyclidine overdoes: An overview. Ann Emerg Med 9:595, 1980. Welch MJ, Correa GA: PCP intoxication in young children and infants. Clin Pediatr 19:510, 1980. References: Misra AL, Pontani RB, Bartolomea J: Persistence of phencyclidine (PCP) and metabolites in brain and adipose tissue. Research Communications in Chemical Pathology and Pharmacology 24:431, 1979 Aronow, R, Done AK: Phencyclidine overdose: An emerging concept of management. J Am Coll Emerg Phys 7:56, 1978 Rappolt RT, Gay GR, Farris RD: Phencyclidine (PCP) intoxication: Diagnosis in stages and algorithms of treatment. Clin Toxicol 16:509, 1980. Sioris LJ, Krenzelok EP: Phencycliidine intoxication: A literature review. Am J Hosp Pharm 35:1362, 1978. McCarron MM, Schulze BW, Thompson GA, et al: Acute phencycline intoxication: Incidence of clinical findings in 1000 cases. Ann Emerg Med 10:237, 1981. Perterson RC, Stillman RC(eds): Phencyclidine (PCP) Abuse: An Appraisal. NIDA Research Monograph 21. DHEW, Washington, DC, Aug 1978. Goode DJ, Meltzer HY: The role os isometric muscle tension in the production of muscle toxicity by phencyclidine and restraint stress. Psychopharmacologia (Berl) 42:105, 1975. The infomation in the report is dated, so if someone is really interested, maybe they can do a current library search. It looks like Clin Toxicol abstracts would be a good place to start. The paper with 1000 cases reviewed also looks interesting to me, I'll try and get a copy. Shawn ============================================================================= Newsgroups: alt.drugs From: firstname.lastname@example.org (William E. White ) Subject: Re: PCP info sought possible FAQ beginnings Message-ID:
Date: Sun, 8 Jan 1995 22:46:54 GMT In article <email@example.com>, Murple wrote: >What a crock of shit. Where did you get this "reliable" book, the PDFA? While I don't believe that PCP (or any other drug for that matter, except maybe alcohol (just kidding)) is an "evil" drug, I believe there is evidence to show that a PCP trip in a naive user can be a very frightening thing. Although the text in question may have shown the extreme to the absence of the normal PCP "trip", I think this is only natural since the only "trips" which would have become relevant to law enforcement would be precisely those which were extreme. Sorta like the phenomenon that the most nutty segments of a group (e.g., televangelists of Christians) tend to be the most noticed. Some things to consider: -- PCP is not necessarily more likely to lead to criminal behaviour than other drugs, and in fact some studes (sorry I don't have references for this one, it's been awhile) show that PCP-intoxicated users are less likely to pose a threat to law enforcement than alcohol-intoxicated users. -- PCP does, however, have a fairly high rate of inducing "bad trips" in users who are naive to its effects, and/or not expecting them. I know several people who *have* obtained PCP laced MJ, occasionally without knowing it (this based on a friend who is experienced with PCP, and sampled the material in question). Furthermore, in some areas PCP is not particularly expensive, and PCP-MJ combinations do tend to show up and be about the same cost as "kind" (e.g., $50 to $75 per quarter ounce). This is regional; YMMV. Yes, this is a shitty thing to do to someone, but sometimes it was unintentional (e.g., friend A "borrows" some of friend B's dope, and sells it to friends C, D, and E). Which just goes to show, know your source. -- In particular, most people who aren't expecting a dissociative anaesthetic can get *quite* disturbed by the experience. Many people find it unpleasantly reminiscent of fever dreams. That, coupled with the lack of feedback from sensory and muscle input, can be a dangerous combination simply because people can injure themselves and not know it. -- PCP shares with alcohol certain effects on ion channels (in particular NMDA), and some of alcohol's "inhibition releasing" effects may be NMDA related as opposed to GABA related. Any drug capable of reducing inhibitions can be undesirable in people not particularly comfortable with themselves. -- PCP's pharmacology (as well as that of ketamine and dizocilpine, and to a lesser extent dextromethorphan and noscapine) is unique in that it affects a set of receptors whose role seems to be much more involved in "ordinary" neurotransmission (*), i.e. the NMDA receptor. Contrast with the indolealkylamines (e.g., LSD), phenylalkylamines, etc., which primarily affect "regulatory" neurotransmitter systems -- 5HT, dopamine, and noradrenaline. -- People expecting to "wig out" on PCP are likely to do so, regardless of whether they would have absent from the expectations. * Actually the NMDA receptors are involved in long-term potention, but I think there's evidence that LTP is involved in more than just hippocampal short-term memory encoding. If nothing else, people with no hippocampi don't show sensory blockade like NMDA antagonists produce. In any case NMDA neurotransmission is widespread and ordinary. In general, although I have not taken PCP myself, I tend to agree that it is not something to be entered lightly. *MANY PEOPLE REACT POORLY TO DISSOCIATIVE ANAESTHETICS* If you don't like the idea of being "out of touch" with your body, feeling cut off from reality like that, it's not for you. -- | Bill White +1-614-594-3434 | firstname.lastname@example.org | | 44 Canterbury, Athens OH 45701 | finger for PGP2.2 block | | http://oucsace.cs.ohiou.edu/personal/bwhite.html (check it out!) |
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