|Oct 12, 1492
|Christopher Columbus lands on the beaches of San Salvador in the West Indies and is offered fruit, wooden spears, and dried tobacco leaves by the natives. 1
|Andre Thevet brought the first tobacco (N. tabacum) to France from Brazil. 1
|Tobacco is dubbed "Nicotina" in honor of Jean Nicot, the French ambassador to Portugal, who sent it from Portugal to the French court as a medicine, beginning its spread in upper-class circles. 2
|Nicotine is first observed as an active product in tobacco juice by French scientist Vauguelin.
|Nicotine is first isolated by Posselt and Reimann at the University of Heidelberg as the primary active ingredient in tobacco. They named it "Nicotine" in honor of Jean Nicot.
|First British cigarette factory opens. 3 [Details]
|My Lady Nicotine is published by Sir James Barrie in London.
|The chemicals structure of nicotine is established by German chemist A. Pinner. 4
|Japan bans the use of cigarettes by anyone under the age of 20. 5
|German scientists propose a link between smoke inhalation and lung cancer. 5
|U.S. Federal Trade Commission releases first tar and nicotine report. 5
|Nicotine gum is first approved by the FDA for prescription use in the United States.
|Nicotine patches are first approved by the FDA for prescription use in the United States. 5
|President Clinton announces a comprehensive anti-smoking program in the U.S. which includes granting the FDA jurisdiction to regulate cigarettes as nicotine delivery devices.
|Nicotine gum is approved for over-the-counter sale in the U.S. in February 1996. Soon thereafter, the nicotine patch is approved for over-the-counter sale in July. [More Info]