Erowid
 
 
Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Have you had an experience with
Peyote, San Pedro, or Synthetic Mescaline?
Help out researchers at Maastricht University and...
Take this Survey!

Nicotine Material Safety Data Sheet(s)

Other Material Safety Information for Nicotine:



  l-Nicotine, 99+%
96314
        **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****
MSDS Name: l-Nicotine, 99+%
Catalog Numbers:
     AC181420000, AC181420050, AC181420250, AC181421000
Synonyms:
     S-(-)-Nicotine, B-Pyridyl-a-N-Methylpyrrolidine.
Company Identification:  Acros Organics N.V.
                         One Reagent Lane
                         Fairlawn, NJ  07410
For information in North America, call:   800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
          **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****
+----------------+--------------------------------------+----------+-----------+
|      CAS#      |              Chemical Name           |    %     |  EINECS#  |
|----------------|--------------------------------------|----------|-----------|
|       54-11-5  |Nicotine                              |    99    | 200-193-3 |
+----------------+--------------------------------------+----------+-----------+
          Hazard Symbols: T+
          Risk Phrases: 25 27
                  **** SECTION 3 - HAZARDS IDENTIFICATION ****
                               EMERGENCY OVERVIEW
Appearance:  colorless to light yellow.
Danger! May be fatal if swallowed. May be fatal if absorbed through
the skin. Hygroscopic. This substance has caused adverse
reproductive and fetal effects in animals. May cause central nervous
system depression. Poison! May cause cardiac disturbances. May cause
digestive tract irritation with nausea, vomiting, and diarrhea.
Target Organs: Central nervous system, respiratory system, muscles.
Potential Health Effects
     Eye:
          May cause eye irritation.
     Skin:
          May cause skin irritation. May be fatal if absorbed through the
          skin.
     Ingestion:
          May be fatal if swallowed. May cause adverse effects of the
          musculature. May cause severe digestive tract irritation with
          abdominal pain, nausea, vomiting and diarrhea. May cause tremors and
          convulsions. May cause muscle paralysis, respiratory failure, and
          possible death.
          Exposure causes initial nervous system stimulation followed by severe
          CNS depression.  May cause ataxia and incoordination.
     Inhalation:
          May cause effects similar to those described for ingestion.
     Chronic:
          May cause digestive tract and cardiac disturbances.
                    **** SECTION 4 - FIRST AID MEASURES ****
     Eyes:
          Immediately flush eyes with plenty of water for at least 15 minutes,
          occasionally lifting the upper and lower lids. Get medical aid.
     Skin:
          Flush skin with plenty of soap and water for at least 15 minutes
          while removing contaminated clothing and shoes. Get medical aid if
          irritation develops or persists. Discard contaminated clothing in a
          manner which limits further exposure. Destroy contaminated shoes.
     Ingestion:
          If victim is conscious and alert, give 2-4 cupfuls of milk or water.
          Get medical aid immediately.
     Inhalation:
          Get medical aid immediately. Remove from exposure to fresh air
          immediately. If not breathing, give artificial respiration. If
          breathing is difficult, give oxygen.
     Notes to Physician:
          Treat symptomatically and supportively.
                  **** SECTION 5 - FIRE FIGHTING MEASURES ****
     General Information:
          As in any fire, wear a self-contained breathing apparatus in
          pressure-demand, MSHA/NIOSH (approved or equivalent), and full
          protective gear. Can form explosive mixtures at temperatures above
          the flashpoint. Vapors may be heavier than air.  They can spread
          along the ground and collect in low or confined areas.
     Extinguishing Media:
          For small fires, use water spray, dry chemical, carbon dioxide or
          chemical foam. Water or foam may cause frothing.
     Autoignition Temperature: 240 deg C ( 464.00 deg F)
     Flash Point: 101 deg C ( 213.80 deg F)
     NFPA Rating: health-4; flammability-1; reactivity-0
     Explosion Limits, Lower: .70 vol %
                       Upper: 4.00 vol %
                **** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****
     General Information: Use proper personal protective equipment as indicated
                          in Section 8.
     Spills/Leaks:
          Avoid runoff into storm sewers and ditches which lead to waterways.
          Wear a self contained breathing apparatus and appropriate Personal
          protection. (See Exposure Controls, Personal Protection section).
          Remove all sources of ignition. Absorb spill using an absorbent,
          non-combustible material such as earth, sand, or vermiculite.
                   **** SECTION 7 - HANDLING and STORAGE ****
     Handling:
          Wash thoroughly after handling. Remove contaminated clothing and
          wash before reuse. Use with adequate ventilation. Ground and bond
          containers when transferring material. Use spark-proof tools and
          explosion proof equipment. Do not reuse this container. Do not get
          on skin or in eyes. Do not ingest or inhale.
     Storage:
          Keep away from sources of ignition. Keep from contact with oxidizing
          materials. Store in a cool, dry, well-ventilated area away from
          incompatible substances. Keep away from strong acids.
          **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****
     Engineering Controls:
          Use adequate general or local exhaust ventilation to keep airborne
          concentrations below the permissible exposure limits.
                                 Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
|   Chemical Name    |        ACGIH      |       NIOSH       |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| Nicotine           |0.5 mg/m3; skin -  |0.5 mg/m3 TWA  5   |0.5 mg/m3 TWA    |
|                    |potential for      | mg/m3 IDLH        |                 |
|                    |cutaneous          |                   |                 |
|                    |absorption         |                   |                 |
+--------------------+-------------------+-------------------+-----------------+
     OSHA Vacated PELs:
          Nicotine:
          0.5 mg/m3 TWA
     Personal Protective Equipment
                 Eyes:
                       Wear appropriate protective eyeglasses or chemical
                       safety goggles as described by OSHA's eye and face
                       protection regulations in 29 CFR 1910.133 or European
                       Standard EN166.
                 Skin:
                       Wear impervious gloves.
             Clothing:
                       Wear appropriate protective clothing to prevent skin
                       exposure.
          Respirators:
                       Follow the OSHA respirator regulations found in 29CFR
                       1910.134 or European Standard EN 149. Always use a
                       NIOSH or European Standard EN 149 approved respirator
                       when necessary.
             **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****
Physical State:             Liquid
Appearance:                 colorless to light yellow
Odor:                       Slight fish odor when warm.
pH:                         10.2
Vapor Pressure:             1 mm Hg @ 61.8C
Vapor Density:              5.61 (air=1)
Evaporation Rate:           Not available.
Viscosity:                  exposure to air
Boiling Point:              247 deg C @ 760.00mm Hg
Freezing/Melting Point:     -80 deg C
Decomposition Temperature:  Not available.
Solubility:                 IN WATER: MISCIBLE BELOW 60ŚC
Specific Gravity/Density:   1.0100g/cm3
Molecular Formula:          C10H14N2
Molecular Weight:           162.23
                 **** SECTION 10 - STABILITY AND REACTIVITY ****
     Chemical Stability:
          Stable at room temperature in closed containers under normal storage
          and handling conditions.
     Conditions to Avoid:
          Incompatible materials.
     Incompatibilities with Other Materials:
          Strong acids, strong oxidizers.
     Hazardous Decomposition Products:
          Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
     Hazardous Polymerization: Has not been reported.
                **** SECTION 11 - TOXICOLOGICAL INFORMATION ****
     RTECS#:
          CAS# 54-11-5: QS5250000
     LD50/LC50:
          CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50
          mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg.
     Carcinogenicity:
       Nicotine -
          Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
     Epidemiology:
          No information available.
     Teratogenicity:
          Effects on Newborn: Biochemical and metabolic, orl-rat
          TDLo=59400 ug/kg; Stillbirth, scu-rat TDLo=9 mg/kg. Embryo or Fetus:
          Death, ipr-mouse TDLo=24 mg/kg; Stunted fetus, ipr-rat TDLo=5250 ug/kg.
          Specific Developmental Abnormalities: Craniofacial, ipr-mouse
          TDLo=1 mg/kg; Musculoskeletal, orl-mouse TDLo=16 mg/kg.
     Reproductive Effects:
          Fertility: Litter size, scu-mouse TDLo=25 mg/kg. Maternal Effects:
          Postpartum effects, scu-rat TDLo=22500 ug/kg.
     Neurotoxicity:
          No information available.
     Mutagenicity:
          DNA Inhibition: rbt-cell types 1mmol/L.
     Other Studies:
          Please refer to RTECS QS5250000 for additional data.
                  **** SECTION 12 - ECOLOGICAL INFORMATION ****
     Ecotoxicity:
          Fish (fresh water) 3-29ppm toxic (time period not specified).
     Environmental Fate:
          No information reported.
     Physical/Chemical:
          No information available.
     Other:
          None.
                 **** SECTION 13 - DISPOSAL CONSIDERATIONS ****
Dispose of in a manner consistent with federal, state, and local regulations.
RCRA D-Series Maximum Concentration of Contaminants:
None listed.
RCRA D-Series Chronic Toxicity Reference Levels: None
listed.
RCRA F-Series: None listed.
RCRA P-Series: CAS# 54-11-5: waste number P075.
RCRA U-Series: None listed.
CAS# 54-11-5 is banned from land disposal according
to RCRA.
                  **** SECTION 14 - TRANSPORT INFORMATION ****
     US DOT
          Shipping Name: NICOTINE
           Hazard Class: 6.1
              UN Number: 1654
          Packing Group: II
     IMO
          No information available.
     IATA
          No information available.
     RID/ADR
          No information available.
     Canadian TDG
          Shipping Name: NICOTINE
           Hazard Class: 6.1
              UN Number: UN1654
                  **** SECTION 15 - REGULATORY INFORMATION ****
 US FEDERAL
     TSCA
          CAS# 54-11-5 is listed on the TSCA inventory.
        Health & Safety Reporting List
          None of the chemicals are on the Health & Safety Reporting List.
        Chemical Test Rules
          None of the chemicals in this product are under a Chemical Test Rule.
        Section 12b
          None of the chemicals are listed under TSCA Section 12b.
        TSCA Significant New Use Rule
          None of the chemicals in this material have a SNUR under TSCA.
     SARA
        Section 302 (RQ)
          CAS# 54-11-5: final RQ = 100 pounds (45.4 kg)
        Section 302 (TPQ)
          CAS# 54-11-5: TPQ = 100 pounds; RQ = 100 pounds (calculated TPQ change
          d after technical review  as described in the technical support docume
          nt)
        SARA Codes
          CAS # 54-11-5: acute, chronic.
        Section 313
          This material contains Nicotine (CAS# 54-11-5, 99%),which is subject
          to the reporting requirements of Section 313 of SARA Title III and
          40 CFR Part 373.
     Clean Air Act:
          This material does not contain any hazardous air pollutants.
          This material does not contain any Class 1 Ozone depletors.
          This material does not contain any Class 2 Ozone depletors.
     Clean Water Act:
          None of the chemicals in this product are listed as Hazardous
          Substances under the CWA.
          None of the chemicals in this product are listed as Priority
          Pollutants under the CWA.
          None of the chemicals in this product are listed as Toxic Pollutants
          under the CWA.
     OSHA:
          None of the chemicals in this product are considered highly hazardous
          by OSHA.
 STATE
     Nicotine can be found on the following state right to know lists:
     California, New Jersey, Florida, Pennsylvania, Minnesota,
     Massachusetts.
     WARNING: This product contains Nicotine, a chemical known to the
     state of California to cause birth defects or other reproductive
     harm.
     California No Significant Risk Level:
     None of the chemicals in this product are listed.
 European/International Regulations
     European Labeling in Accordance with EC Directives
          Hazard Symbols: T+
          Risk Phrases:
                       R 25  Toxic if swallowed.
                       R 27  Very toxic in contact with skin.
          Safety Phrases:
                       S 36/37  Wear suitable protective clothing and
                       gloves.
                       S 45  In case of accident of if you feel unwell, seek
                       medical advice immediately (show the label where
                       possible).
   WGK (Water Danger/Protection)
          CAS# 54-11-5: No information available.
   Canada
          CAS# 54-11-5 is listed on Canada's DSL/NDSL List.
          This product has a WHMIS classification of D1A, D2B.
          CAS# 54-11-5 is not listed on Canada's Ingredient Disclosure List.
   Exposure Limits
          CAS# 54-11-5: OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin
          OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin
          OEL-BELGIUM:TWA 0.5 mg/m3;Skin
          OEL-DENMARK:TWA 0.5 mg/m3;Skin
          OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin
          OEL-FRANCE:TWA 0.5 mg/m3;Skin
          OEL-GERMANY:TWA 0.07 ppm (0.5 mg/m3);Skin
          OEL-HUNGARY:STEL 0.5 mg/m3;Skin
          OEL-THE NETHERLANDS:TWA 0.07 ppm (0.5 mg/m3);Skin
          OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin
          OEL-POLAND:TWA 0.5 mg/m3
          OEL-SWITZERLAND:TWA 0.07 ppm (0.5 mg/m3);STEL 0.1 ppm;Skin
          OEL-THAILAND:TWA 0.5 mg/m3
          OEL-TURKEY:TWA 0.5 mg/m3;Skin
          OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin
          OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
          OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
                  **** SECTION 16 - ADDITIONAL INFORMATION ****
     MSDS Creation Date:  2/01/1996  Revision #1 Date: 12/16/1997
     The information above is believed to be accurate and represents the best
     information currently available to us. However, we make no warranty of
     merchantability or any other warranty, express or implied, with respect to
     such information, and we assume no liability resulting from its use. Users
     should make their own investigations to determine the suitability of the
     information for their particular purposes. In no way shall Fisher be liable
     for any claims, losses, or damages of any third party or for lost profits
     or any special, indirect, incidental, consequential or exemplary
     damages, howsoever arising, even if Fisher has been advised of
     the possibility of such damages.
--------------------------------------------------------------------------------