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Interactions Between MAOIs, SSRIs, and Recreational Drugs
by Erowid

  1. Avoid mixing MAOIs and SSRIs.
    This can lead to serotonin syndrome and can be dangerous.

  2. Do not mix MAOIs with Stimulants (including MDMA).
    This can lead to hypertensive crisis and can be deadly.

  3. SSRIs in Combination with MDMA
    Generally reduces the effects of the MDMA significantly.

  4. SSRIs in Combination with Psychedelics
    Generally reduce the effects of the psychedelic a bit.

  5. MAOIs in Combination with Psychedelics
    Generally increase the effects of the psychedelic significantly. Be extremely careful.

Strong SSRIs are significantly more common than MAOIs. Many commonly prescribed pharmaceutical anti-depressants are SSRIs, including Prozac (Fluoxetine), Paxil (Paroxetine), Zoloft (Sertraline), Celexa (Citalopram), and Desyrel (Trazodone).

Strong MAOIs are less common, but include prescription anti-depressants like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), l-deprenyl (Eldepryl), moclobemide (Aurorex or Manerix), furazolidone, and pargyline. Ayahuasca also contains MAOIs, generally in the form of Banisteriopsis caapi or Syrian rue (harmine and harmaline).