- Avoid mixing MAOIs and SSRIs.
- Do not mix MAOIs with Stimulants (including MDMA).
- SSRIs in Combination with MDMA
- SSRIs in Combination with Psychedelics
- MAOIs in Combination with Psychedelics
This can lead to serotonin syndrome and can be dangerous.
This can lead to hypertensive crisis and can be deadly.
Generally reduces the effects of the MDMA significantly.
Generally reduce the effects of the psychedelic a bit.
Generally increase the effects of the psychedelic significantly. Be extremely careful.
Strong SSRIs are significantly more common than MAOIs. Many commonly prescribed pharmaceutical anti-depressants are SSRIs, including Prozac (Fluoxetine), Paxil (Paroxetine), Zoloft (Sertraline), Celexa (Citalopram), and Desyrel (Trazodone).
Strong MAOIs are less common, but include prescription anti-depressants like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), l-deprenyl (Eldepryl), moclobemide (Aurorex or Manerix), furazolidone, and pargyline. Ayahuasca also contains MAOIs, generally in the form of Banisteriopsis caapi or Syrian rue (harmine and harmaline).