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Listed below are some of the known interactions between LSD and other chemicals, plants or pharmaceutical medications. This is not a comprehensive list.

Dangerous Lithium or tricyclics (like Amitriptyline, Anafranil, Asendin, Aventyl, Elavil, Endep, Norfranil, Norpramin, Pamelor, Sinequan, Surmontil, Tipramine, Tofranil, Vivactil) are fairly consistently reported as being very bad in combination with LSD. People attempting this combination are unable to communicate with others, they go into "fugue states" where they end up in other places and don't know how they got there, and they are generally in a terrible place psychologically. Life-threatening seizures and at least one death have been reported to be triggered by the combination of LSD and lithium. seizures, fugue state Credible
Related Case Reports
LSD and Antidepressants.
Dangerous Although no data exists directly about an interaction between Ritonavir and LSD, several case reports have been published in medical journals where individuals have had extremely severe adverse events after taking ergotamine and similar ergolines in combination with Ritonavir. Irreversible coma (Pardo Rey 2003), amputations (Liaudet 1999), numbness, and other symptoms of ergotism (severe vascular constriction) have been strongly linked to this combination. Because LSD's doses are so much lower than ergotamine and LSD is rarely used chronically, interactions of this type may not occur between Ritonavir and LSD. Ergotamine is also thought to interact dangerously with other pharmaceuticals such as erythromycin (Eadie 2001). There is no clinical data to suggest those other drugs cause dangerous interactions with LSD. This effect could also occur with other anti-viral metabolized through the same pathways. nausea, vomiting, cephalagia, peripheral-ischemia, extremity-pain, cyanosis Tentative
Related Case Reports
Liaudet 1999
Pardo Rey 2003
Caballero-Granado FJ 1997
Rosenthal 1999
Eadie 2001
SSRIs Decreased Effects SSRIs (like Prozac, Paxil, Zoloft, Celexa, Desyrel) or MAOIs (like Nardil, Parnate, Marplan, Eldepryl, Aurorix, Manerix) are consistently reported to noticeably reduce the effects of LSD. MAOIs seem to cause a greater reduction in the effects of LSD than SSRIs. seizures, fugue state Credible
Related Case Reports
LSD and Antidepressants.
If you have a positive or negative drug interaction to report, please let us know! Submit an interaction.
  • Ischemia : Localized reduction in blood flow or anemia in some body part resulting from vasoconstriction, thrombosis, or embolism.
  • Cyanosis : Blueing of skin or lips.
Erowid's interactions information is a summary of data gathered from first hand reports, research, and other resources. This page is intended to collect drug-drug and biology-drug interactions and is not exhaustive: other dangerous or medically important interactions may exist that are not listed here. Drug effects may vary dramatically from one person to another and from one experience to another based on a variety of factors such as body chemistry, age, gender, physical health, dose, and form of material.

  1. Liaudet L, Buclin T, Jaccard C, Eckert P. Drug points: severe ergotism associated with interaction between ritonavir and ergotamine. BMJ. 1999;318(7186):771
  2. Parto Rey C, Yebra M, Borrallo M, Vega A, Ramos A, Montero MC. Irreversible coma, ergotamine, and ritonavir. Clin Infect Dis. 2003;37(5):e72-3
  3. Caballero-Granado FJ, Viciana P, Cordero E, Gomez-Vera MJ, del Nozal M, Lopez-Cores LF. Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient. Antimicrob Agents Chemother. 1997;41(5):1207
  4. Rosenthal E, Sala F, Chichmanian RM, Batt M, Cassuto JP. Ergotism related to concurrent administration of ergotamine tartrate and indinavir. JAMA. 1999;281(11):987a>
  5. Eadie MJ. Clinically significant drug interactions with agents specific for migraine attacks. CNS Drugs. 2001;15(2):105-18
  6. Tatro DS, Olin BR, Hebel SK et al. Drug Interaction Facts, St-Louis, Missouri: Facts and comparaisons. 2002.