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LSA Analog Notes
by Erowid & JH

Because LSA is Schedule III, analogs of LSA are not covered under the Federal Analogue Act.

By Donald A. Cooper while working for the DEA:
"Because of previously noted pharmacodynamics and the imposing nature of a total synthesis, the immediate precursor of a LSD derivative synthesis will most certainly be a controlled substance, namely lysergic acid, therefore, much of the impetus for producing noncontrolled LSD derivatives is lost. However, if the CsA (Controlled Substances Act) amendment were not a consideration there would be a clear first choice via substitution of the indole nitrogen to create either 1-alkyl or 1-acyl derivatives. Derivatives of this type most probably fall under the purview of the CsA amendment. The N,N-methylpropyl isomer Of LSD has been the only derivative of LSD examined by the author. Derivatives of this type might seem to be an unlikely choice for a Ca due to a high probability of significant loss in hallucinogenic activity.

However, a reduction in hallucinogenic activity may become acceptable to the U.S. clandestine chemist when he notes that lysergic acid amide is listed as a Schedule III substance in the CFR; therefore, structuarly similar substances of this compound are exempted from the CsA amendment. A lucid argument can then be made that lysergic acid N,N-dimethylamide is derived from lysergic acid amide rather than LSD. Carrying this theme to the next logical step one would then assume that the 1-alkyl and 1-acyl derivatives of the N,N-dimethyl isomer would also not be controlled by the CsA amendment. At present, no known CsA of LSD has ever been encountered by the DEA."