From NIH's National Toxicology Program, October 2001.
NTP CHEMICAL REPOSITORY GAMMA-VALEROLACTONE -IDENTIFIERS =========== *CATALOG ID NUMBER: 002172 *CAS NUMBER: 108-29-2 *BASE CHEMICAL NAME: VALEROLACTONE,GAMMA- *PRIMARY NAME: GAMMA-VALEROLACTONE *CHEMICAL FORMULA: C5H8O2 *STRUCTURAL FORMULA: Not printable *WLN: Not available *SYNONYMS: DIHYDRO-5-METHYL-2(3H)-FURANONE 4-HYDROXYPENTANOIC ACID LACTONE 4-HYDROXYVALERIC ACID LACTONE GAMMA-METHYL-GAMMA-BUTYROLACTONE 4-METHYL-GAMMA-BUTYROLACTONE GAMMA-PENTALACTONE 4-PENTANOLIDE 4-VALEROLACTONE 4-HYDROXYPENTANOIC ACID GAMMA-LACTONE 4-METHYLBUTYROLACTONE TETRAHYDRO-5-METHYL-2-FURANONE DIHYDRO-5-METHYL-2-FURANONE 5-METHYLTETRAHYDRO-2-FURANONE 4-HYDROXYVALERIC ACID GAMMA-LACTONE 5-METHYLBUTYROLACTONE -PHYSICAL CHEMICAL DATA ====================== *PHYSICAL DESCRIPTION: LITERATURE: Colorless, mobile liquid REPOSITORY: Clear colorless liquid *MOLECULAR WEIGHT: 100.12 *SPECIFIC GRAVITY: 1.057 @ 20/4 C [269,275] *DENSITY: 1.0465 g/mL @ 25 C [017,047] *MP (DEG C): -31 C [017,205,269,275] *BP (DEG C): 207-208 C [205,269,275] *SOLUBILITIES: WATER : >=100 mg/mL @ 22 C (RAD) DMSO : >=100 mg/mL @ 22 C (RAD) 95% ETHANOL : >=100 mg/mL @ 22 C (RAD) METHANOL : Not available ACETONE : >=100 mg/mL @ 22 C (RAD) TOLUENE : Not available OTHER SOLVENTS: Most organic solvents: Miscible  Most resins: Miscible  Most waxes: Miscible  Zein: Slightly miscible  Beeswax: Slightly miscible  Petrolatum: Slightly miscible  Anhydrous glycerin: Immiscible  Glue: Immiscible  Casein: Immiscible  Arabic gum: Immiscible  Soybean protein: Immiscible  *VOLATILITY: Vapor pressure: 0.5 mm Hg @ 29 C; 3.5 mm Hg @ 51 C; 11.5 mm Hg @ 73 C  Vapor density : 3.45 *FLAMMABILITY(FLASH POINT): This chemical has a flash point of 81 C (178 F) [205,269,275]. It is combustible. Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used . *UEL: Not available LEL: Not available *REACTIVITY: This chemical is incompatible with strong oxidizing agents [042,269]. It is also incompatible with strong acids, strong bases and strong reducing agents . *STABILITY: This chemical is stable under normal laboratory conditions. Solutions of this chemical in water, DMSO, 95% ethanol or acetone should be stable for 24 hours under normal lab conditions (RAD). *OTHER PHYSICAL DATA: Specific gravity: 1.0518 @ 25/25 C [042,062] Boiling point: 83-84 C @ 13 mm Hg [017,025,047] Flash point (open cup): 96 C (205 F) [042,062] Refractive index: 1.4330 @ 20 C; 1.4301 @ 25 C Crystallizing point: -37 C pH (anhydrous): 7.0 pH (10% solution in distilled water): 4.2 Vapor pressure: 41.5 mm Hg @ 97 C  -TOXICITY ======== *NIOSH REGISTRY NUMBER: LU3580000 *TOXICITY: (abbreviations) typ. dose mode specie amount units other LDLo ims gpg 2500 mg/kg LD50 orl rat 8800 mg/kg LD50 orl rbt 2480 mg/kg *AQTX/TLM96: Not available *SAX TOXICITY EVALUATION: THR: MODERATE via oral route. LOW via oral route. *CARCINOGENICITY: Not available *MUTATION DATA: test lowest dose | test lowest dose ----------- ----------------- | ----------- ----------------- Not available | *TERATOGENICITY: Not available *STANDARDS, REGULATIONS & RECOMMENDATIONS: OSHA: None ACGIH: None NIOSH Criteria Document: None NFPA Hazard Rating: Health (H): None Flammability (F): None Reactivity (R): None *OTHER TOXICITY DATA: Skin and Eye Irritation Data: skn-rbt 500 mg/24H MLD Status: EPA TSCA Chemical Inventory, 1986 -OTHER DATA (Regulatory) ======================= *PROPER SHIPPING NAME (IATA): Not restricted *UN/ID NUMBER: *HAZARD CLASS: SUBSIDIARY RISK: PACKING GROUP: *LABELS REQUIRED: *PACKAGING: PASSENGER: PKG. INSTR.: MAXIMUM QUANTITY: CARGO : PKG. INSTR.: MAXIMUM QUANTITY: *SPECIAL PROVISIONS: *USES: Constituent of crude pyroligneous acid, in dye baths (coupling agent), brake fluid, cutting oils and as a solvent for adhesives, insecticides and lacquers. *COMMENTS: This compound is derived from furfural. -HANDLING PROCEDURES =================== *ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is an irritant of the skin, eyes, mucous membranes and upper respiratory tract . When heated to decomposition it emits acrid smoke and fumes of carbon monoxide and carbon dioxide [042,269]. *MINIMUM PROTECTIVE CLOTHING: Not available *RECOMMENDED GLOVE MATERIALS: GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical: This chemical has not been tested for permeation by Radian Corporation; however, the GlovES+ expert system was used to extrapolate permeation test information from compounds in the same chemical class. The GlovES+ system uses permeation data from literature sources; therefore, extra safety margins should be used with the estimated protection time(s). If this chemical makes direct contact with your glove, or if a tear, puncture or hole develops, replace them at once. The GlovES+ expert system is a tool that can help people better manage protection from chemicals, however this tool cannot replace sound judgment nor make technical decisions. Our GlovES+ expert system is designed to offer initial advice and assistance in glove selection while the final glove selection should be made by knowledgeable individuals based on the specific circumstances involved. Glove Type Model Number Thickness Estimated Protection Time Butyl rubber North B-174 0.68 mm 240 min. Polyvinyl alcohol Edmont 25-545 Unknown 240 min. *RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH- approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. *OTHER: Not available *STORAGE PRECAUTIONS: You should store this chemical at ambient temperatures, and keep it away from oxidizing materials. *SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. *DISPOSAL AND WASTE TREATMENT: Not available -EMERGENCY PROCEDURES ==================== *SKIN CONTACT: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. *INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Respirator Recommendation. *EYE CONTACT: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. *INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. *SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and upper respiratory tract . -SOURCES ======= *SOURCES:  Lewis, R.J., Sr. and R.L. Tatken, Eds. Registry of Toxic Effects of Chemical Substances. Microfiche Ed. National Institute for Occupational Safety and Health. Cincinnati, OH. Quarterly Updates. LU3580000.  Weast, R.C., M.J. Astle, and W.H. Beyer, Eds. CRC Handbook of Chemistry and Physics. 67th Ed. CRC Press, Inc. Boca Raton, FL. 1986. p. C-545, #14846.  Buckingham, J., Ed. Dictionary of Organic Compounds. 5th Ed. Chapman and Hall. New York. 1982. Vol. 2, pp. 1869-1870, #D-03890.  Sax, N.I. Dangerous Properties of Industrial Materials. 6th Ed. Van Nostrand Reinhold. New York. 1984. p. 2716.  Weast, R.C. and M.J. Astle, Eds. CRC Handbook of Data on Organic Compounds. CRC Press, Inc. Boca Raton, FL. 1985. Vol. II, p. 427, #V00077.  Sax, N.I. and R.J. Lewis Sr., Eds. Hawley's Condensed Chemical Dictionary. 11th Ed. Van Nostrand Reinhold. New York. 1987. p. 1214.  U.S. Environmental Protection Agency, Office of Toxic Substances. Toxic Substances Control Act Chemical Substance Inventory: 1985 Edition. 5 Vols. U.S. Environmental Protection Agency. Washington, D.C. January 1986. Listed.  Oak Ridge National Laboratory. Environmental Mutagen Information Center (EMIC), Bibliographic Data Base. Oak Ridge National Laboratory. Oak Ridge, TN. Not listed.  Oak Ridge National Laboratory. Environmental Teratogen Information Center (ETIC), Bibliographic Data Base. Oak Ridge National Laboratory. Oak Ridge, TN. Not listed.  Dean, John A., Ed. Lange's Handbook of Chemistry. 13th Ed. McGraw-Hill Book Company. New York. 1985. p. 7-687, #v1.  Grayson, Martin, Ed. Kirk-Othmer Encyclopedia of Chemical Technology. Volumes 1-24 and Supplement. 3rd Ed. John Wiley & Sons. New York. 1978-1984. Vol. 11, p. 508.  Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data. Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985. p. 1828, #C.  Aldrich Chemical Company. Aldrich Catalog/Handbook of Fine Chemical. Aldrich Chemical Co., Inc. Milwaukee, WI. 1988. p. 1530, #V40-3.  Safety Consulting Engineers Inc. Vapor Pressure Test Results for Twelve Materials. Report Number 111053-LR. Safety Consulting Engineers Inc. Rosemont, IL. August 5, 1988.  Clansky, Kenneth B., Ed. Suspect Chemicals Sourcebook: A Guide to Industrial Chemicals Covered Under Major Federal Regulatory and Advisory Programs. Roytech Publications, Inc. Burlingame, CA. 1990. Not listed.  United States National Toxicology Program. Chemical Status Report. NTP Chemtrack System. Research Triangle Park, NC. November 6, 1990. Not listed. -------------------------------------------------------------