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GHB (Sodium Oxybate)
Interactions
by Erowid
SUMMARY #
Listed below are some of the known interactions between GHB and other chemicals, plants or pharmaceutical medications. This is not a comprehensive list.

POSSIBLE DRUG INTERACTIONS SUMMARY
GHB
SUBSTANCETYPEDESCRIPTIONSYMPTOMSCONFIDENCEREFS
Alcohol (Beer, Wine, Spirits) Dangerous Alcohol can combine dangerously with GHB. At low levels, it increases inebriation, dizziness, vertigo, and vomiting. At higher doses of either GHB or alcohol, unconsciousness, suppressed gag reflex, and respiratory depression have been reported. Hospitalizations and deaths have occurred. vertigo, vomiting, respiratory depression, death Verified Case Reports FDA Warning.
Sedatives
Benzodiazepines
Dangerous Sedatives such as benzodiazepines like xanax, valium and the related Z-sleep drugs (zolpidem, zaleplon, and zopiclone) can combine dangerously with GHB, enhancing respiratory depression, and (like alcohol) increasing risk of vomiting and unpleasant effects. nausea, vomiting, unconsciousness, respiratory depression Confirmed
Related Case Reports
FDA Warning
If you have a positive or negative drug interaction to report, please let us know! Submit an interaction.
Definitions:
CAUTION & DISCLAIMER #
Erowid's interactions information is a summary of data gathered from first hand reports, research, and other resources. This page is intended to collect drug-drug and biology-drug interactions and is not exhaustive: other dangerous or medically important interactions may exist that are not listed here. Drug effects may vary dramatically from one person to another and from one experience to another based on a variety of factors such as body chemistry, age, gender, physical health, dose, and form of material.