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GHB MSDS

From: http://hazard.com/msds/tox/tf/q39/q172.html

                      *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ET4750000
CHEMICAL NAME           : Butyric acid, 4-hydroxy-, sodium salt
CAS REGISTRY NUMBER     : 502-85-2
LAST UPDATED            : 199701
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C4-H7-O3.Na
MOLECULAR WEIGHT        : 126.10
WISWESSER LINE NOTATION : Q3VO &-NA-
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Gamma OH
   * 4-Hydroxybutyric acid sodium salt
   * gamma-Hydroxybutyrate sodium salt
   * Sodium gamma-hydroxybutyrate
   * Sodium 4-hydroxybutyrate
   * Sodium oxybate
   * Somsanit
   * WY-3478
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 71 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - coma
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 9,321,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9690 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 43,714,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 32,375,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - alteration of classical conditioning
   Skin and Appendages - hair
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 17,30,1967
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE                    : 40 mg/kg
SEX/DURATION            : female 68 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 100,72,1968

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***



From :Seton Resource Center.com


 4-Hydroxybutyric Acid, Sodium Salt, 99%  ACROS20292

        **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION ****

MSDS Name: 4-Hydroxybutyric Acid, Sodium Salt, 99%
Catalog Numbers:
     AC121060000, AC121060250, AC121061000, AC9477256, AC9489246, AC9505779,
     NC9592938, XXAC12106-15 kg, XXAC12106-1 kg
Synonyms: Sodium Oxybate

Company Identification (Europe):  Acros Organics N.V.
                                  Janssen Pharmaceuticalaan 3a
                                  2440 Geel, Belgium
Company Identification (USA):     Acros Organics
                                  One Reagent Lane
                                  Fairlawn, NJ  07410
For information in North America, call:   800-ACROS-01
For information in Europe, call:          0032(0) 14575211
For emergencies in the US, call CHEMTREC: 800-424-9300
For emergencies in Europe, call:     0032(0) 14575299

          **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
|      CAS#      |              Chemical Name           |    %     |  EINECS#  |
|----------------|--------------------------------------|----------|-----------|
|      502-85-2  |4-Hydroxybutyric Acid, Sodium Salt    |   99%    | 207-953-3 |
+----------------+--------------------------------------+----------+-----------+

                  **** SECTION 3 - HAZARDS IDENTIFICATION ****

                               EMERGENCY OVERVIEW
Appearance:  white to off-white.
Caution! May cause reproductive effects based upon animal studies.
May cause respiratory and digestive tract irritation.
Target Organs: None known.

Potential Health Effects
     Eye:
          No information regarding eye irritation and other potential effects
          was found.
     Skin:
          No information regarding skin irritation and other potential effects
          was found.
     Ingestion:
          Ingestion of large amounts may cause gastrointestinal irritation.
     Inhalation:
          Inhalation of dust may cause respiratory tract irritation.
     Chronic:
          Not available.

                    **** SECTION 4 - FIRST AID MEASURES ****

     Eyes:
          Flush eyes with plenty of water for at least 15 minutes,
          occasionally lifting the upper and lower eyelids. Get medical aid
          immediately.
     Skin:
          Get medical aid immediately. Flush skin with plenty of soap and
          water for at least 15 minutes while removing contaminated clothing
          and shoes.
     Ingestion:
          If victim is conscious and alert, give 2-4 cupfuls of milk or water.
          Never give anything by mouth to an unconscious person. Get medical
          aid immediately.
     Inhalation:
          Get medical aid immediately. Remove from exposure to fresh air
          immediately. If not breathing, give artificial respiration. If
          breathing is difficult, give oxygen.
     Notes to Physician:
          Treat symptomatically and supportively.

                  **** SECTION 5 - FIRE FIGHTING MEASURES ****

     General Information:
          As in any fire, wear a self-contained breathing apparatus in
          pressure-demand, MSHA/NIOSH (approved or equivalent), and full
          protective gear.
     Extinguishing Media:
          In case of fire, use water fog, dry chemical, carbon dioxide, or
          regular foam.

                **** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

     General Information: Use proper personal protective equipment as indicated
                          in Section 8.
     Spills/Leaks:
          Sweep up or absorb material, then place into a suitable clean, dry,
          closed container for disposal.

                   **** SECTION 7 - HANDLING and STORAGE ****

     Handling:
          Wash thoroughly after handling. Use only in a well ventilated area.
          Avoid contact with eyes, skin, and clothing. Avoid ingestion and
          inhalation.
     Storage:
          Store in a cool, dry place. Keep container closed when not in use.

          **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

     Engineering Controls:
          Use adequate ventilation to keep airborne concentrations low.

                                 Exposure Limits
+--------------------+-------------------+-------------------+-----------------+
|   Chemical Name    |        ACGIH      |       NIOSH       |OSHA - Final PELs|
|--------------------|-------------------|-------------------|-----------------|
| 4-Hydroxybutyric Ac|none listed        |none listed        |none listed      |
| id, Sodium Salt    |                   |                   |                 |
+--------------------+-------------------+-------------------+-----------------+

     OSHA Vacated PELs:
          4-Hydroxybutyric Acid, Sodium Salt:
             No OSHA Vacated PELs are listed for this chemical.

     Personal Protective Equipment

                 Eyes:
                       Wear appropriate protective eyeglasses or chemical
                       safety goggles as described by OSHA's eye and face
                       protection regulations in 29 CFR 1910.133 or European
                       Standard EN166.
                 Skin:
                       Wear appropriate protective gloves to prevent skin
                       exposure.
             Clothing:
                       Wear appropriate protective clothing to prevent skin
                       exposure.
          Respirators:
                       Follow the OSHA respirator regulations found in 29CFR
                       1910.134 or European Standard EN 149. Always use a
                       NIOSH or European Standard EN 149 approved respirator
                       when necessary.

             **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State:             Powder
Appearance:                 white to off-white
Odor:                       None reported.
pH:                         Not available.
Vapor Pressure:             Not available.
Vapor Density:              Not available.
Evaporation Rate:           Not available.
Viscosity:                  Not available.
Boiling Point:              @ 760.00mm Hg
Freezing/Melting Point:     144 - 148 deg C
Autoignition Temperature:   Not available.
Flash Point:                Not available.
NFPA Rating:                 Not published.
Explosion Limits, Lower:    Not available.
                  Upper:    Not available.
Decomposition Temperature:
Solubility:                 soluble
Specific Gravity/Density:
Molecular Formula:          C4H7O3Na
Molecular Weight:           126.09

                 **** SECTION 10 - STABILITY AND REACTIVITY ****

     Chemical Stability:
          Stable under normal temperatures and pressures.
     Conditions to Avoid:
          Not available.
     Incompatibilities with Other Materials:
          Strong oxidizing agents.
     Hazardous Decomposition Products:
          Carbon monoxide, carbon dioxide, sodium oxide.
     Hazardous Polymerization: Has not been reported.

                **** SECTION 11 - TOXICOLOGICAL INFORMATION ****

     RTECS#:
          CAS# 502-85-2: ET4750000
     LD50/LC50:
          CAS# 502-85-2: Oral, rat: LD50 = 9690 mg/kg.
     Carcinogenicity:
       4-Hydroxybutyric Acid, Sodium Salt -
          Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
     Epidemiology:
          No data available.
     Teratogenicity:
          No data available.
     Reproductive Effects:
          Experimental reproductive effects have been reported.
     Neurotoxicity:
          No data available.
     Mutagenicity:
          No data available.
     Other Studies:
          No data available.

                  **** SECTION 12 - ECOLOGICAL INFORMATION ****



                 **** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Chemical waste generators must determine whether a discarded chemical is classif
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Part
Additionally, waste generators must consult state and local hazardous waste regu
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

                  **** SECTION 14 - TRANSPORT INFORMATION ****

     US DOT
          No information available
     Canadian TDG
          No information available.

                  **** SECTION 15 - REGULATORY INFORMATION ****

 US FEDERAL
     TSCA
          CAS# 502-85-2 is listed on the TSCA inventory.
        Health & Safety Reporting List
          None of the chemicals are on the Health & Safety Reporting List.
        Chemical Test Rules
          None of the chemicals in this product are under a Chemical Test Rule.
        Section 12b
          None of the chemicals are listed under TSCA Section 12b.
        TSCA Significant New Use Rule
          None of the chemicals in this material have a SNUR under TSCA.
     SARA
        Section 302 (RQ)
          None of the chemicals in this material have an RQ.
        Section 302 (TPQ)
          None of the chemicals in this product have a TPQ.
        Section 313
          No chemicals are reportable under Section 313.
     Clean Air Act:
          This material does not contain any hazardous air pollutants.
          This material does not contain any Class 1 Ozone depletors.
          This material does not contain any Class 2 Ozone depletors.
     Clean Water Act:
          None of the chemicals in this product are listed as Hazardous
          Substances under the CWA.
          None of the chemicals in this product are listed as Priority
          Pollutants under the CWA.
          None of the chemicals in this product are listed as Toxic Pollutants
          under the CWA.
     OSHA:
          None of the chemicals in this product are considered highly hazardous
          by OSHA.
 STATE
     4-Hydroxybutyric Acid, Sodium Salt is not present on state lists from
     CA, PA, MN, MA, FL, or NJ.
     California No Significant Risk Level:
     None of the chemicals in this product are listed.
 European/International Regulations
     European Labeling in Accordance with EC Directives
          Hazard Symbols: Not available.
          Risk Phrases:
          Safety Phrases:
                       S 24/25  Avoid contact with skin and eyes.
   WGK (Water Danger/Protection)
          CAS# 502-85-2: No information available.
   United Kingdom Occupational Exposure Limits

   Canada
          None of the chemicals in this product are listed on the DSL/NDSL list.
          WHMIS: Not available.
          CAS# 502-85-2 is not listed on Canada's Ingredient Disclosure List.
   Exposure Limits

                  **** SECTION 16 - ADDITIONAL INFORMATION ****

     MSDS Creation Date:  9/02/1997  Revision #1 Date:  8/02/2000

     The information above is believed to be accurate and represents the best
     information currently available to us. However, we make no warranty of
     merchantability or any other warranty, express or implied, with respect to
     such information, and we assume no liability resulting from its use. Users
     should make their own investigations to determine the suitability of the
     information for their particular purposes. In no way shall the company be
     liable for any claims, losses, or damages of any third party or for lost
     profits or any special, indirect, incidental, consequential or exemplary
     damages, howsoever arising, even if the company has been advised of
     the possibility of such damages.
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