|Late 8th Century
|Burial site in N. Chile includes bag with snuffing paraphernalia and snuff remnants containing DMT, 5-MeO-DMT, and bufotenin. Other sites include seeds of Anadenanthera spp.
|Ritual bundle found in a funerary site in SW Bolivia contains remnants of DMT, Harmine, Bufotenine, Cocaine, and possibly Psilocin, along with snuff tablets, a snuff tube, llama bone scrapers, and a head band. The find is notable because of the presence of a number of psychoactive chemicals, as well as the combined presence of DMT and Harmine. 1 [More Info]
|Friar Ramon Pane documented the use of a psychoactive snuff called cohoba/yopo among the Taino who inhabited the island of Hispaniola Haiti/Dominican Republic. It is now agreed that cohoba/yopo was almost certainly made from Anadenanthera peregrina, which has been reported to contain N,N-DMT, 5-MeO-DMT, and bufotenin. 2 [Details]
|Indians along the Rio Guaviare in Colombia take yopo along with tobacco.
|16th - 19th Century
|Cohoba snuff from the yopo tree used by natives of Columbia and surrounding areas.
|Incan medicine men make prophecies through inebriation brought about by drinking vilca, a DMT containing preparation of A. colubrina.
|A Jesuit writes about cohoba use by the native people between Colombia and Venezuela.
|Baron Alexander Humboldt identified the yopo tree as Anadenanthera peregrina
|DMT first synthesized by British chemist Richard Manske and named "nigerine".
|Virola genus identified as the source of a psychoactive snuff called epena used in Amazoniana Columbia, Venezuela and Western Brazil.
|n,n-DMT is identified as one of the ingredients of the A. peregrina seeds used to make cohoba snuff. This marked the first time that n,n-DMT was discovered naturally occuring in a plant or animal. Authors speculate that it is psychoactive. 3
|First scientific publication verifying the psychoactive properties of DMT by Stephen Szara. 4 [Details] [More Info]
|U.S.: The Bureau of Drug Abuse Control notes in Microgram that DMT is available on the street, both as a powder, and "impregnated on marihuana and tea". 5
|N,N-DMT becomes illegal in the U.S. with the passage of the 1971 Convention on Psychotropic Substances.