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5-MeO-DIPT User's Guide v1.0

by Loosenut

Copyright information: This document may be freely copied and distributed as long as: 1) no profit is made, and 2) this message as well as the rest of the information remain intact and unmodified. The most current copy of this document can always be found at the Lycæum.

Responsible Use | Dosage & Effects | Combinations | Afterword

Recently 5-MeO-DIPT (N,N-Diisopropyl-5-methoxytryptamine) has become available on the "research chemical" market. This compound has proven to be quite interesting, both as a recreational substance and as a tool for serious psychonautic exploration. It has earned the nickname of "Foxy Methoxy", due, I would assume, to its ability to pleasantly enhance tactile sensation.

At the time of this writing, 5-MeO-DIPT is not illegal in the United States. [Erowid note: On April 4, 2003, 5-MeO-DiPT was placed into Schedule I through the emergency scheduling procedure. It is now illegal to buy, sell or possess without a DEA license.] Through the spread of accurate information and by encouraging responsible use, perhaps we can prevent this wonderful material from becoming yet another casualty of the War on Drugs.

5-MeO-DIPT should be white/tan in appearance. As an indole alkaloid derivative, it has a strong indole smell and taste which most people find unpleasant. Like other related subtances, it acts as a potent serotonergic agonist. If being stored on a long-term basis, one should place it in an airtight container, kept in a cool, dark location.

In many individuals, 5-MeO-DIPT produces an acute nausea and/or vomiting. There have been reports of using Loperamide (the active ingredient in anti-diarrhea medication such as Immodium) to combat the unpleasant body load produced by this material.

Responsible Use
5-MeO-DIPT is an extremely potent material. If you do not have a scale/balance accurate to at least 1 mg, it is very easy to overdose. It is not a good idea to "eyeball" a dose of this substance, as the dose-to-response curve is extremely steep.

By learning from the past, perhaps we can help 5-MeO-DIPT avoid the same legal fate as other psychedelics. Under NO circumstances should this material be marketed for human consumption. This would be immoral, illegal, and outright stupid. 2C-B [Lycaeum info, Erowid info], a phenethylamine possessing similar aphrodesiac qualities, was quickly illegalized after a company started marketing it for human use.

As with all mind-altering substances, certain common-sense precautions exist with this drug. Do not drive a car, operate heavy machinery, etc. while under its influence. Do not give this drug to people who have not researched it beforehand. It should not be used if you are pregnant, nursing, or not of a mature emotional level. If you have a pre-existing medical or psychological condition, you would be well-advised to avoid this material as well.

Dosage & Effects
Onset, duration, and effects vary according to individual metabolism and neurochemistry. Other factors that may affect the trip: whether or not you have a full stomach (fasting for at least 12 hours prior is recommended); psychological/emotional state one is experiencing when they dose; the environment it is taken in, etc. These variables are true of all psychedelics. Personally, I have found that the best setting is at home with the lights dimmed, playing mellow music and hanging out with loved ones. Generally, the effects build for roughly 2 hours, at which point you reach the peak and gradually float down for about 4-6 hours more. Some users report insomnia following the journey.

5-MeO-DIPT develops a tolerance after you take it- meaning that unless you wait several days to a week before taking it again, you will either not feel it, barely feel it, or need to take more to reach the level you want to be at. Cross-tolerance with LSD has also been reported.

Orally: At lower doses (5-10 mg), 5-MeO-DIPT induces a warm, pleasant state in which tactile and aural sensations may also be enhanced. Many people have commented that at this dosage range it possesses wonderful aphrodesiac qualities. As the dosage increases past the 10 mg mark, the effects become increasingly psychedelic, producing vivid visuals and mental phenomenon similar to LSD or Psilocybe mushrooms. Taking over 25 mg at once is not recommended (at the time of this writing, 5-MeO-DIPT has caused no human deaths. Let's keep it that way.)

Insufflated: This route presents the benefit of a shorter trip and less body load. However, even though the amount of material is quite small, the burn is quite signifigant and the taste from the post-nasal drip is extremely unpleasant.

Smoked: If you are chemically inclined, the hydrochloride salt of 5-MeO-DIPT can be converted into a freebase and smoked. This route, like the insufflated route, offers the advantage of a shorter and less nauseous journey. Unlike potent smokable tryptamines such as DMT, 5-MeO-DMT, and DPT Freebase, all of which cause an intense, fast-moving psychedelic voyage lasting only about 10 minutes, 5-MeO-DIPT comes on slowly and lasts for several hours when taken in this manner.

Intramuscular/Intraveneous: No information available.

Rectally: No information available.

"Booster Doses": There have been reports of taking booster doses to prolong the effects. Since tolerance does not develop signifigantly until after the peak of the trip, the best way to take supplemental doses is to wait until shortly before the peak.

5-MeO-DIPT has been shown to have a dynamic synergy with other substances. Here is a brief list of some of the known combinations:

2C-B: When combined with 2C-B, the visual, tactile, and aural effects are astounding, and at times overwhelming. One should anticipate increased body load and/or vomiting when exploring this particular combination.

Cannabis: As with GHB, Cannabis works well for easing psychic tension associated with tripping. Unlike GHB, however, Cannabis can make you mentally "cloudy" and less lucid for the journey.

Dipropyltrypamine: A special synergy exists here. This is a particularly mind-blowing combination, not recommended for people who are new to the entheogenic experience.

Ecstasy: No information available, reports forthcoming.

GHB: I have found GHB to be great at easing the "psychic anxiety" experienced during the onset of 5-MeO-DIPT (as well as other psychedelics). Likewise, it can be a welcome sedative at the tail end of the journey, helping to counteract the insomnia which many users experience. Most people take a higher dose of GHB than usual when on a psychedelic, otherwise the effects are barely noticeable.

Harmine/Harmaline ("Foxyhuasca"): The addition of Harmala alkaloids adds a dimension of profundity and spiritual awakening to the experience. This combination, as one would expect, is subjectivally similar to the traditionally used visionary brew Ayahuasca [Erowid Info,]. This particular combination has not been explored to great lengths, but will likely prove to be an intense ayahuasca analog for use by experienced psychonauts only.

Ketamine: One user reported this combination to be scary and unpleasant. In my opinion, 5-MeO-DIPT is not the ideal psychedelic to mix K with, for various reasons. One of the primary factors weighing against this particular combo is the body load produced. Also, the ketamine greatly overpowers this substance, leaving many of the desirable effects of 5-MeO-DIPT unnoticeable.

LSD: No information available, reports forthcoming. I suspect 5-MeO-DIPT would not contribute signifigantly and would be largely overpowered by the acid experience.

This is not intended to be a scientific document. The sources used to compile this document are largely anecdotal, based on my personal experiences, interviews with others familiar with this material, and trip reports.

The purpose of this document is not to encourage the use of this drug- in fact, I hope I have dissuaded many of you from exploring with this substance at all. I created this document with the hope that those of you who do decide to experiment will be better-informed and less likely to end up in the emergency room freaking out on a bad trip.

Recommended reading:

September 6, 1999: Initial release (v1.0). Aug 1, 2003: Erowid : delete dead link. Jan 19, 2007: Erowid : update legal status, links.