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4-Methylmethcathinone (Mephedrone, 4-MMC)
by Erowid
4-Methylmethcathinone is a synthetic stimulant with euphoric and empathogenic effects that gained popularity in the U.K., Ireland, Australia, and Europe between 2007 and 2009. The effects of 4-methylmethcathinone are often compared to those of MDMA, MBDB, bk-MDMA (methylone), cocaine, methamphetamine and other euphoric stimulants. Because of its short duration and intense rush, there are numerous reports of compulsive redosing, resulting in the use of more 4-methylmethcathinone than intended.
A standard oral dose of 4-methylmethcathinone is between 75 and 200 mg. It is most frequently found as a powder, though a few tablets have been commercially produced.
Price #
As of November 2009, 4-methylmethcathinone is primarily sold online and is available for as low as $20 (USD) for a single gram, with bulk pricing as low as $15 (USD) per gram.
4-Methylmethcathinone is temporarily Schedule I in the United States and it would be considered an illegal analogue of methcathinone if intended for human consumption. 4-methylmethcathinone is controlled in a number of countries, including Australia, Denmark, Germany, New Zealand, Sweden, and the United Kingdom.
4-Methylmethcathinone is a synthetic chemical similar in structure to methcathinone.
Pharmacology #
Pharmacology Summary Needed.
Production #
Production Summary Needed.
History #
Little has been published about the history of 4-methylmethcathinone prior to its introduction into the world online markets in 2007. The first country to ban it by name was Israel in December 2007.
Terminology / Slang #
The Substance:
Mephedrone, 4-MMC, Meow, M-Cat, Bubbles
The Experience:
Onset #
Depending on how much and how recently one has eaten food, oral 4-methylmethcathinone generally takes 15-45 minutes to take full effect. On a full stomach, onset can be considerably slower. When insufflated, effects are usually felt within a few minutes and the peak is reached within 30 minutes or less.
Duration #
The primary effects of 4-methylmethcathinone last approximately 2-3 hours when taken orally. For many people there is an additional period of time (1-4 hrs) where it is difficult to go to sleep but where mood and mind-set are mostly back to baseline. It is quite common for users to report a strong urge to redose as the effects wane, between 45 and 120 minutes after initial ingestion. With lower levels of consumption, the day-after effects are relatively mild, with most users reporting light to no hangover. Heavy users report worrying neurological and vasoconstrictive symptoms that can last days or weeks.
Visual Effects #
Visuals Summary Needed.
Nausea, teeth-clenching, compulsive redosing, heart palpitations, racing heart, increased blood pressure, and other effects of high dose stimulants.

Contraindications #
  • Do not take 4-methlmethcathinone if you are currently taking an MAOI. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Ayahuasca also contains MAOIs (harmine and harmaline). Stimulants and MAOIs are a potentially dangerous combination. Check with your doctor if you are not sure whether your prescription medication is an MAOI.
  • At strong doses, do not operate heavy machinery. Do Not Drive.
  • If you have a seizure or convulsive disorder or heart problems, you may be at higher risk for health problems when taking stimulants.
Addiction Potential #
4-Methylmethcathinone is not likely to cause much physical dependence or withdrawal symptoms, but many users report difficulty controlling their own use within a short period of time. It is unknown whether use might lead to long-term psychological addiction and related problems, but it is likely that 4-methylmethcathinone could be one of a number of stimulants that are part of a pattern of stimulant overuse.
Long-Term Health Problems #
There have been reports of vasoconstriction with repeated dosing, including moderate to severe symptoms of tingling and numbness in the extremities, headache, light-headedness and worrisome skin discoloration.
Risk of Death #
Risks of death associated with stimulants usually involve cardiovascular problems, overheating, and dangerous drug interactions as well as accidents related to intoxication and multi-drug combinations. 4-methylmethcathinone has been associated with several deaths, but details of the circumstances of these incidents are scanty.
Erowid Basics pages are summaries of data gathered from site visitors, government documents, books, websites, and other resources. We do our best to keep this information correct and up-to-date, but the field is complex and constantly changing. Information should always be verified through multiple sources.