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Davis WM, Bedford JA, Buelke JL, Guinn MM, Hatoum HT, Waters IW, Wilson MC, Braude MC.
“Acute toxicity and gross behavioral effects of amphetamine, four methoxyamphetamines, and mescaline in rodents, dogs, and monkeys”.
Toxicol Appl Pharmacol. 1978 Jul 29;45(1):49-62.
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Abstract
Mescaline MES and d-amphetamine AMP served as reference agents in a study of acute toxic and behavioral effects of four methoxy derivatives of AMP: dl-4-methoxyamphetamine PMA, dl-2,5-dimethoxyamphetamine DMA, dl-2,5-dimethoxy-4-bromoamphetamine DOB, and dl-2,5-dimethoxy-4-methylamphetamine DOM.
Acute 24-hr LD50 values were determined in mice iv and oral, rats ip, and dogs iv.
Estimation of the iv lethal dose range for each agent was conducted in a small number of rhesus monkeys. In terms of millimoles per kilogram of the base, MES was consistently the least toxic, whereas DOB or DOM was the most toxic for all species except the mouse. AMP was the most toxic for the mouse and was third in toxicity for all other species. At lethal and sublethal doses of these agents, observations were made for their effects on automatic, motor, and CNS functions and on behaviors possibly correlating with human hallucinogenic effects. According to the resulting profiles, DMA, DOM, and DOB had effects most similar to those of MES, whereas PMA had more in common with AMP. However, PMA, like the other three derivatives and mescaline, caused visual tracking in monkeys and dogs, a sign which may reflect a hallucinatory action.
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