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Hansen G, Jensen SB, Chandresh L, Hilden T.
“The psychotropic effect of ketamine”.
J Psychoactive Drugs. 1988 Oct-Dec 02;20(4):419-25.
Ketamine, a drug used for intravenous (ID and intramuscular
(IM) anesthesla" was originally intoduced into
clinical usage in 1970. It is in widespread use worldwide and
is considered to be an extremely safe anesthetic because it
does not cause circulatory or respiraory depression. Ketamine's
action is analgesic and anesthetic, withoutbeing hypnotic
as normally construed. Its action is presumed to result
from selective inhibition of associative pathways connecting
the thalamoneocortical and limbic systems as well as
from selective inhibition and stimulation in these two systems,
respectively. The resulting state has been termed "dissociative
anesthesia." A survey of the literature by White,
Way and Trevor (1982) contained an update on the drug's
pharmacology. Ketamine is recommended for use with
children and with patients in generally poor health. During
the past few years, ketamine has replaced ether as the
anesthetic of choice of the Danish military health corps, especially
for use in frontline zones (Gronfeldt 1983).