Recently, with the reintroduction of iproniazid as a "psychic energizer," a great deal of interest has been stimulated in the chemical treatment of seriously depressed patients. The search for effective agents for the treatment of depression has been encouraged by the failure of tranquilizers to provide relief in most severe depressions. Preliminary studies with 2-amino-1-(3,4-methylene-dioxyphenyl)-propane hydrochloride (SKF #5) [MDA] led us to feel that it might be a useful drug in this area.
