Erowid.org: Erowid Reference 7170 : Comparison of biological effects of N-alkylated congeners of beta-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene : Cannon JG, Perez JA, Pease JP, Long JP, Flynn JR, Rusterholz DB, Dryer SE

Erowid References Database

Cannon JG, Perez JA, Pease JP, Long JP, Flynn JR, Rusterholz DB, Dryer SE. “Comparison of biological effects of N-alkylated congeners of beta-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene”. J Med Chem. 1980 Jul 24;23(7):745-9. <a name="ref">Cannon JG, Perez JA, Pease JP, Long JP, Flynn JR, Rusterholz DB, Dryer SE.</a> <a href="/references/7170">"Comparison of biological effects of N-alkylated congeners of beta-phenethylamine derived from 2-aminotetralin, 2-aminoindan, and 6-aminobenzocycloheptene"</a> <i>J Med Chem</i>. 1980 Jul 24;23(7):745-9.
Show Articles by Cannon JG Perez JA Pease JP Long JP Flynn JR Rusterholz DB Dryer SE Article IDs Erowid RefID: 7170 PubMedID: 7190613 Collections Hofmann Collection MDMA Collection All References	Abstract Three series of bicyclic, semirigid congeners of beta-phenethylamine have been prepared for evaluation of the effect of ring size (and of concomitant conformational variation) on biological activity in a variety of assays for adrenergic and dopaminergic actions. Pharmacologic activity was associated with 2-aminotetralin and 2-aminoindan derivateves, but was not found with 6-aminobenzocycloheptene derivatives. Noteworthy is the ability of several aminotetralins and aminoindans to increase the hot-plate reaction time without eliciting dopaminergic effects. This action was not blocked by pretreatment with naloxone.
Comments and Responses to this Article #
Submit Comment

[ Cite HTML ]