Erowid Needs Your End-of-the-Year Support
We're an educational non-profit dedicated to providing a balanced
examination of psychoactive drugs and drug use--to reduce harms,
improve benefits, and support appropriate policies. The site is made
possible by $5, $10, and $50 donations from visitors. Please pitch in!

Erowid References Database

Soriano SG, Anand KJ. 
“Anesthetics and brain toxicity”. 
Curr Opin Anaesthesiol. 2005 Jun;18(3):293-7.
PURPOSE OF REVIEW: Recent experimental data from rodent studies have demonstrated accelerated neurodegeneration in rat pups exposed to commonly used anesthetic drugs. These provocative findings certainly question and undermine the safe use of anesthetic drugs, particularly in pediatric anesthesia, and have prompted many to investigate the neurotoxic effect of anesthetic drugs on the developing brain. This review will address the scientific evidence for the anesthetic-induced neurotoxicity and its applicability in humans. RECENT
FINDINGS: Several investigators have shown that prolonged administration of anesthetic drugs, including ketamine, isoflurane, nitrous oxide and midazolam, produced increased neurodegeneration in 7-day-old rat pups. The combination of the latter three drugs led to altered learning behavior in adulthood. Despite these unequivocal findings in rodents, similar changes cannot be reproduced in other species. Furthermore, withholding anesthesia during painful procedures in neonatal rats resulted in significant long-term aberrant responses to sensory stimulation and pain thresholds. SUMMARY: Taken together, these studies question the applicability of these data to the anesthetic management of the neonate. Further investigations in this area are needed before withholding anesthetics in the anesthetic management of pediatric surgical patients.
Submit Comment
[ Cite HTML ] Plants & Drugs Mind & Spirit Freedom & Law Arts & Sciences Search About Erowid and Feedback Library & Bookstore Copyrights Memberships noref