Shaman Women, Plant Medicine, & Psychedelics Salon
This event will examine different ways that power can be misused in ceremonies that use plants as sacraments, and practical steps that participants can take to protect themselves.
Vancouver Canada, Nov 14 - 15, 2014

Erowid References Database

Nicholse DE, Frescas S. 
“Improvements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin”. 
Synthesis. 1999;6:935-938.
Abstract
Abstract: An improved procedure to accomplish the O-phosphorylation of 4-hydroxy-N,N-dimethyltryptamine (psilocin 5) is reported that utilizes reaction between the O-lithium salt of 5 and tetra-Obenzylpyrophosphate. The O-benzyl groups were removed by catalytic hydrogenation over palladium on carbon to afford N,N-dimethyl- 4-phosphoryloxytryptamine (psilocybin, 1). In view of difficulties encountered in the preparation of 1, it is suggested that 4-acetoxy-N,N-dimethyltryptamine (2) may be a useful alternative for pharmacological studies. The latter was obtained following catalytic O-debenzylation of 4-benzyloxy-N,N-dimethyltryptamine in the presence of acetic anhydride and sodium acetate.
Key Words: psilocin, psilocybin, tetra-O-benzylpyrophosphate, phosphorylation
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