Erowid References Database
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Grob C, Bravo G, Walsh R.
“Second thoughts on 3,4-methylenedioxymethamphetamine (MDMA) neurotoxicity”.
Arch Gen Psychiatry. 1990;47(3):288-9.
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Abstract
Recent attention has been drawn to the purported neurotoxic dangers associated with 3, 4-methylenedioxymethamphetamine (MDMA). Price et al have attempted to assess possible serotonergic neurotransmitter damage by contrasting serum prolactin response to the challenge with intravenous L-tryptophan in subjects with a history of MDMA use vs control subjects. Their primary finding was a blunted rise in the expected serum prolactin level in MDMA users, but not to a statistically significant degree. The importance of this finding appears to be questionable and perhaps misleading. Even if the data had yielded a statistically significant result, would such a correlation necessarily imply causation?
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