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Landis C, Clausen J.
“Certain effects of mescaline and lysergic acid on psychological functions”.
J. Psychol.. 1954;38:211.
Patients in the early stage of schizophrenia were used as subjects in a tapping test, in the determination of the critical flicker-fusion threshold and in the Purdue Pegboard test. Five of these patients received synthetic mescaline sulphate intravenously, six ingested lysergic acid (d-LSD-25), and four served as a control. The tests were repeated several days prior to the administration of the drug, and 1 1/2 hours, 6 hours, and 24 hours following the administration.
1. In spite of the marked effect of mescaline and lysergic acid on sensation, perception, and general symptomatology of the mental patient, it was possible to measure quantitatively the changes in efficiency reflected by the objective ttst scores.
2. If the drug induced hallucinatory experience, the changes in test scores tended to be more consistent.
3. Injection of mescaline resulted in a marked mean drop for the group in Tapping and Purdue Pegboard scores l 1/2 hours following injection which decrease was still apparent 24 hours after injection in the Purdue Assembly and Tapping Endurance scores.
4. Ingestion of lysergic acid (d-LSI)-25) produced visual hallucinations in three of six patients. The group mean Purdue RLB score was decreased and the other three motor test scores somewhat increased 1 1/2 hours after ingestion. Six hours after ingestion, except for tapping speed, all group means for the psychomotor tests were reduced, and the scores for the two higher levels of brightness at which CFF was determined were somewhat increased.
5. Analysis of the change in direction of test score performance for each individual concerned showed that when the patient was hallucinated by the drug the individual test results were fairly uniform. Mescaline generally resulted in decreased motor test and lower CFF scores 1 1/2 hours after injection. Lysergic acid usually produced decreased motor test scores and increased CFF thresholds for the highest level of luminance six hours after ingestion.