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Fischer R, Agnew N.
“On drug-produced experimental psychoses”.
Wool protein was used as a model of the structural surface
of receptors, possibly involved in the mechanism producing
an experimental (model) psychosis by drugs).
Hence the affinity for wool of the following compounds
was determined at PH 5.2 : mescaline hydrochloride, methedrine
(pervitine) hydrochloride, lysergic acid monoethylamide (LAE)
and lysergic acid diethylamide (LSD), the latter two in
form of their methanoltartrates. These drugs, if administered
to humans in the approximate range of dosage: 500 mg.,
100 mg., 1 mg. and 100 y respectively, cause an experimental
psychosis characterized by hallucinations and related phenomena
of similar intensity and duration.
|Notes # : (auch LAE 3b)