Erowid References Database
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Teal JJ, Holtzman SG.
“Discriminative Stimulus Effects of Cyclazocine in the Rat”.
J.Pharmacol Exp.Ther.. 1980;212(3):368-76.
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Abstract
The discriminative stimulus effects of cyclazocine (CZ) were studied. Methods Groups of CFE rats (160-400 g) were trained to discriminate either 0.3 or 1.0 mg/kg CZ (Sterling-Winthrop), respectively, from saline. All drugs were given s.c. 30 Min before the start of session except in time course studies. A 2-choice discrete trial avoidance paradigm was used. Behavior was considered to be under stimulus control when a rat could reliably complete at least 18 trials of a 20-trial session on the correct choice lever. Once an animal had met this criteria, drug substitution testing was begun. Results CZ engendered dose-related CZ-appropriate responding in both groups of rats, with the position of the dose-response curves along the abscissa reflecting the differences in training dose. The time course of the discriminative effects of CZ was maximal at 30 min. and drug-appropriate responding began to decline by 1 hr reaching that of saline control by 240 min. Although the stimulus effects of the training doses of CZ could not be completely blocked by naltrexone (NX), 0.3 mg/kg NX shifted the CA dose response curves to the right so that a comparable degree of stimulus control was noted only with 3x the training dose of CZ. Ketocyclazocine (Sterling-Winthrop) and SKF 10-047 (SK+F) produced stimulus effects comparable to those produced by both training doses of CZ as determined by the number of trials completed on the drug-appropriate lever. Ethylketocyclazocinentazocine (Sterling-Winthrop) and levallorphan (Roche) produced stimulus effects comparable with only the lower dose of CZ, whilst morphine (Mallinckrodt) and nalorphine (Merck-USA) produced stimulus effects on comparable with either dose of CZ. Ketamine (Parke-Davis) and phencyclidine both mimicked the discriminative effects of CZ but mescaline (Aegis), d-amphetamine (SK+F) and LSD did not. The stimulus effects of both ketamine (10 mg/kg) and phencyclidine (3.0 mg/kg) were completely unaffected by 10 mg/kg naloxone.
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