Erowid References Database
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Keller HH, Burkard WP, da Prada M.
“Lisuride and D-LSD: Effects on the monoaminergic system in the rat brain”.
Experientia. 1977;33(6):806.
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Abstract
The effects of lisuride and D-LSD on rat brain monoamines were studied. The ergot derivative lisuride hydrogen maleate (LIS) injected .i.p. to rats in doses as low as 0.05 mg/kg induced, similarly to D-LSD, a decrease in homovanillic acid (EVA) and 5-hydroxyindoltacetic acid (5-HIAA) in the whole brain with minor changes of the dopamine (DA) and 5-hydroxytryptamine (5-HT) levels. In the striatum and the limbic forebrain, LIS reduced HVA to about the same degree. LIS and to a lesser extent D-LSD induced a dose-dependent increase of 3-methoxy-4-hydroxyphenylethyleneglycal Isulfate in the whole brain. In the n.caudatus and in the n.accumbens septi, LIS and D-LSD counteracted the accumulation of L-DOPA induced by reserpine + NSD 1015 (a decarboxylase inhibitor). In striatal homogenates LIS and D-LSD blocked the DA-induced activation of the adenylate cyclase (AC), whilst D-LSD, but not LIS, mutated per se AC. In limbic slices, both drugs antagonized the activation of AC induced by noradrenaline (NA). Conclusions Both LIS and D-LSD stimulate pre- and postsynaptic DA and 5-HT receptors and block NA receptors at higher doses.
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