Erowid References Database
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Goodrich CA, Hoff KM, Baker PC.
“The Maturational Effects of LSD upon Brain Weight and Behavior in the Mouse.”.
Comp Gen Pharmacol. 1974;5(2):153-155.
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Abstract
The effects of LSD upon mouse behavior and brain weight during maturation were investigated. Methods Male and female CFW mice were given i.p. doses of 0.5, 5.0 or 50.0 mcg/kg LSD on days 1 or 7 post-partum. The animals were allowed to grow to maturity and tested at 8 wk. Behavior was tested by the 'head poke' test. Brain weights were takenfrom freshly killed mice. Results The head poke test showed no significant differences between control and LSD-injected mice of both sexes. There was however a significant reduction in brain weights for male animals injected on day 1. Hemispheres and mescephalon-diencephalon showed a significant reduction only at the 50.0 mcg/kg doses, and the medulla-pons showed reduced weights at the 5.0 and 50.0mcg/kg doses, the greatest reduction being at the highest dose. Males injected on day 7, and all the females, showed no brain weight changes.
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