Erowid References Database
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Sumpf C.
“Mechanisms of the neuropharmacological influences on the EEG”.
Electroenceph Clin Neurophysiol. 1974;36:430.
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Abstract
For a clarification of the effective mechanism and the point of action of centrally active drugs using electrophysiological methods, one examines customarily the influence on evoked potentials. On some examples it will be shown that for this purpose' pharmacologicaliv produced alterations of the spontaneous electrical brain activity may also be employed. For this purpose the septum-hippocampus system and the cerebelium - nucleus ruber system of the rabbit have been shown to be especially suitable. In both systems there is a regularization of electrical activity after application of certain drugs (in the hippocampus after eserin and other anticholhesterases. as shell as after amribetamine and similar drugs: in the cerebellum and nucleus tuber after barbiturates and other hypnotic drugs) where the frequency of the evoked rhythm depends on the dose and on the blood level of the applied drug. Besides. in both systems there is a definite correlation between the activity of single neurones and the EEG (in the septum - hippocampal system between the activity of single neurones of the medial septal nucleus and the hippocampal EEG; in the cerebellum-nucleus ruber systetm between the activity of the neurones of medial septal nucleus from which can be disturbed by certain drugs. Thus LSD leads to flattening of the hippocampal EEG without influencing the activity of the neurons of the said septal nucleus. from which it can be concluded that LSD within the septum hippocampal system. blocks conduction betas een the septum and hippocampus thus flattening the hippocampal EEG. As an example of an analysis of the pharmacological effect on the cerebellum-nucleus tuber system it should be mentioned that after lesions of the brachium conjunctivuin, a phartmacologically caused regularization of the nucleus ruber activity can no longer take place. Thus. for the effect of the drugs in question on the activity of the nucleus ruber, certainly no direct influence on the neurones of that nucleus can be held responsible.
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