Erowid References Database
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Monnier M, Krupp P.
“Classification électro-physiologique des stimulants du système nerveux central. II. Action des stimulants hallucinogènes, psychotoniques, analeptiques sur les mecanismes d'èveil et de détente”.
Arch. Int. Pharmacodyn.. 1960;127:377-360.
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Abstract
On the nonanesthetized rabbit with implanted electrodes, LSD (30-50 mcg/kg i.v.) induces an arousal reaction, that is , desynchronization at the level of the neocortex (motor cortex) and synchronization at the level of the paleocortex (hippocampus) and accentuates the arousal reaction triggered by electric stimulation (150 c/s) of the mesencephalic reticular formation or by sensory stimulation. The potentials induced by stimulation (3 c/s) of the reticular formation of the paleocortex and of the median nodes of the thalamus are accentuated. The reaction (at 2 peaks) to stimulation of the thalamus is rather weak and is only limited to the first peak. This reaction is caused by stimulation of a part of the reticular system which crosses this region. The second peak which is triggered after the medial thalamic system ("recruiting") is lowered with LSD. On the "isolated brain", that is, after intracollicular section of the medula, the effect on the spontaneous EEG is absent. . Psilocybin (2 mg/kg i.v.) exerts a similar effect to LSD on the EEG; but contrasting to LSD, this effect is also exerted on the isolated brain. Psilocybin only accentuates the arousal reaction minimally by means of sensory stimulations and not at all by electric stimulation of the reticular formation and Psilocybin only affects the first peak of potential triggered by medical thalamic stimulation by means of the inhibition which it exerts on the second peak similar to LSD. In contract to LSD, however, it also inhibits the effect caused by stimulation of the hippocampus.
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