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Herold M, Cahn J, Dubrasquet M, Alano J, Barré N, Buret JP.
“Contribution á un concept biochimique des psychoses experiméntales. V. Prévention des modifications du métabolisme cérébral induites par l'intoxication chronique au LSD 25 chez le lapin in vivo. Action de l'adrénaline, de l'éphedrine, de la phentolamine, du bromure de pyridostigmine.”.
Compt. rend. Soc. biol.. 1958;152:45-49.
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Abstract
The changes in cerebral metabolism of rabbits caused by chronic administration of LSD (Cf. Cahn et al., Compt. rend. Soc. biol. Paris 151: 1820, 1957) were antagonized by simultaneous administration of epinephrine, ephedrine, phentolamine or pyridostigmine bromide. The EEG was restored to normal by epinephrine in 500f animals, by ephedrine in 80% and by phentolamine and pyridostigmine bromide in 100%. . A possible explanation is that phentolamine inhibits the LSD-induced sympathicotonia, preventing the collapse of autonomic regulation resulting from chronic administration of LSD, while the effects of epinephrine, ephedrine and pyridostigmine bromide on the EEG are due to a synchronizing action.
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