Erowid is a one-of-a-kind resource
We are an educational non-profit dedicated to providing a balanced
examination of psychoactive drugs and drug use--to reduce harms,
improve benefits, and support appropriate policies. The site is made
possible by $5, $10, and $50 donations from visitors. Please pitch in!

Erowid References Database

Woolley DW, Shaw E. 
“Some neurophysiological aspects of serotonin.”. 
Brit. Med. J.. 1954 /II;II:122.
Abstract
This paper summarizes the findings of investigations made during the past few years on serotonin. Three classes of naturally occurring alkaloids, the ergot alkaloids (LSD, Gynergen and ergotoxine), the harmala alkaloids, and yohimbine, have been shown to have in common: an indole nucleus and a substituted amino-ethyl side-chain; competitive antagonism of serotonin; and, at least one member of each class causes mental aberrations, e.g. LSD. It is thought that the mental changes induced by such drugs may be the result of interference with the action of serotonin in the brain. However, if this were the case, serotonin should reverse the mental effects of the drugs. Studies in mice with LSD and medmain showed that serotonin failed to overcome the neurological effects of the drugs.
Submit Comment
[ Cite HTML ]



Erowid.org Plants & Drugs Mind & Spirit Freedom & Law Arts & Sciences Search About Erowid and Feedback Library & Bookstore Copyrights Memberships noref