Erowid.org: Erowid Reference 470 : Spectral and inhibitory interactions of (+/-)-3,4-methylenedioxyamphetamine (MDA) and (+/-)-3,4-methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes : Brady JF, Di Stefano EW, Cho AK

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Brady JF, Di Stefano EW, Cho AK. “Spectral and inhibitory interactions of (+/-)-3,4-methylenedioxyamphetamine (MDA) and (+/-)-3,4-methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes”. Life Sci. 1986;39(16):1457-64. <a name="ref">Brady JF, Di Stefano EW, Cho AK.</a> <a href="/references/470">"Spectral and inhibitory interactions of (+/-)-3,4-methylenedioxyamphetamine (MDA) and (+/-)-3,4-methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes"</a> <i>Life Sci</i>. 1986;39(16):1457-64.
Text Abstract (this page) Full Text - English (private) Show Articles by Brady JF Di Stefano EW Cho AK Article IDs Erowid RefID: 470 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Incubation of racemic methylenedioxyamphetamine (MDA) or methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes, in the presence of NADPH, generated a spectrally observed inhibitory complex with cytochrome P-450. The complex inhibited product formation from MDA and MDMA as well as other P-450 dependent reactions such as benzphetamine demethylation and CO binding. In the absence of NADPH, MDMA and MDA generated type I and type IIa difference spectra, respectively, suggesting differences in their binding to the enzyme active site. The N-demethylation of MDMA was partially inhibited by methimazole suggesting involvement of the hepatic flavin-containing monooxygenase.
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