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DARK Classics in Chemical Neuroscience: Salvinorin A.
Hernández-Alvarado RB, Madariaga-Mazón A, Ortega A, Martinez-Mayorga K. Hernández-Alvarado RB, et al. ACS Chem Neurosci. 2020 Dec 2;11(23):3979-3992. doi: 10.1021/acschemneuro.0c00608. Epub 2020 Nov 9. ACS Chem Neurosci. 2020. PMID: 33164503 Review.
The worldwide spread and psychotropic effects of salvinorin A account for its misuse and classification as a drug of abuse. Consequently, salvinorin A and Salvia divinorum are now banned in many countries. ...
The worldwide spread and psychotropic effects of salvinorin A account for its misuse and classification as a drug of abuse. Co …
Chemical syntheses of the salvinorin chemotype of KOR agonist.
Hill SJ, Brion AUCM, Shenvi RA. Hill SJ, et al. Nat Prod Rep. 2020 Nov 18;37(11):1478-1496. doi: 10.1039/d0np00028k. Nat Prod Rep. 2020. PMID: 32808003 Free PMC article. Review.
Covering: 2000 to 2020 The hallucinogenic diterpene salvinorin A potently and selectively agonizes the human kappa-opioid receptor (KOR). ...Total synthesis efforts have delivered multiple, orthogonal routes to salvinorin A, its congeners and related a …
Covering: 2000 to 2020 The hallucinogenic diterpene salvinorin A potently and selectively agonizes the human kappa-opioid rece …
Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects.
Brito-da-Costa AM, Dias-da-Silva D, Gomes NGM, Dinis-Oliveira RJ, Madureira-Carvalho Á. Brito-da-Costa AM, et al. Pharmaceuticals (Basel). 2021 Feb 3;14(2):116. doi: 10.3390/ph14020116. Pharmaceuticals (Basel). 2021. PMID: 33546518 Free PMC article. Review.
The main bioactive compound underlying the hallucinogenic effects, salvinorin A, is a non-nitrogenous diterpenoid with high affinity and selectivity for the k-opioid receptor. ...Salvinorin A is rapidly distributed, with accumulation in the brain, and …
The main bioactive compound underlying the hallucinogenic effects, salvinorin A, is a non-nitrogenous diterpenoid with high af …
A review of salvinorin analogs and their kappa-opioid receptor activity.
Roach JJ, Shenvi RA. Roach JJ, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1436-1445. doi: 10.1016/j.bmcl.2018.03.029. Epub 2018 Mar 12. Bioorg Med Chem Lett. 2018. PMID: 29615341 Free PMC article. Review.
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for next-generation analgesics. ...Extensive peripheral modifications using isolated salvinorin A have delivered a trove of SAR info …
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for ne …
Salvinorin a and related compounds as therapeutic drugs for psychostimulant-related disorders.
dos Santos RG, Crippa JA, Machado-de-Sousa JP, Hallak JE. dos Santos RG, et al. Curr Drug Abuse Rev. 2014;7(2):128-32. doi: 10.2174/1874473708666150107122741. Curr Drug Abuse Rev. 2014. PMID: 25563442 Review.
Salvinorin A and its analogues have demonstrated anti-addiction effects in animal models using psychostimulants by attenuating dopamine release, sensitization, and other neurochemical and behavioral alterations associated with acute and prolonged administration of t
Salvinorin A and its analogues have demonstrated anti-addiction effects in animal models using psychostimulants by attenuating
Salvinorin A: from natural product to human therapeutics.
Vortherms TA, Roth BL. Vortherms TA, et al. Mol Interv. 2006 Oct;6(5):257-65. doi: 10.1124/mi.6.5.7. Mol Interv. 2006. PMID: 17035666 Review.
Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the kappa opioid receptor (KOR) has been identified, in vitro and in vivo, as its molec …
Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is …
Formal Total Synthesis of Salvinorin A.
Halang M, Maier ME. Halang M, et al. ChemistryOpen. 2022 Oct;11(10):e202200015. doi: 10.1002/open.202200015. Epub 2022 Feb 26. ChemistryOpen. 2022. PMID: 35218166 Free PMC article.
The generation of the quaternary stereocenter at the C9 position of salvinorin A precursors by the Claisen rearrangement was investigated. ...The major isomer could be converted to a key intermediate of the Hagiwara synthesis of salvinorin A....
The generation of the quaternary stereocenter at the C9 position of salvinorin A precursors by the Claisen rearrangement was i …
Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.
Butelman ER, Kreek MJ. Butelman ER, et al. Front Pharmacol. 2015 Sep 8;6:190. doi: 10.3389/fphar.2015.00190. eCollection 2015. Front Pharmacol. 2015. PMID: 26441647 Free PMC article. Review.
Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. ...Salvinorin A is the only selective KOPr ligand to be widely available outside research or medical settings, and salvinorin A-containing produ
Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. ...Salvinorin A is
Salvinorin A analogs and other kappa-opioid receptor compounds as treatments for cocaine abuse.
Kivell BM, Ewald AW, Prisinzano TE. Kivell BM, et al. Adv Pharmacol. 2014;69:481-511. doi: 10.1016/B978-0-12-420118-7.00012-3. Adv Pharmacol. 2014. PMID: 24484985 Free PMC article. Review.
Unfortunately, classic kappa-opioid agonists have undesired side effects such as sedation, aversion, and depression, which restrict their clinical use. Salvinorin A (Sal A), a novel kappa-opioid receptor agonist extracted from the plant Salvia divinorum, has been id …
Unfortunately, classic kappa-opioid agonists have undesired side effects such as sedation, aversion, and depression, which restrict their cl …
Salvinorin A inhibits ovalbumin-stimulated allergic rhinitis and RBL-2H3 cells degranulation.
Shou Q, Tan T, Xu F. Shou Q, et al. FEBS Open Bio. 2021 Aug;11(8):2166-2173. doi: 10.1002/2211-5463.13219. Epub 2021 Jun 25. FEBS Open Bio. 2021. PMID: 34092045 Free PMC article.
The expression levels of histamine, beta-hexosaminidase, interleukin-4 and tumor necrosis factor-alpha were decreased by salvinorin A in vitro. Granule release and F-actin organization were also suppressed by salvinorin A. ...Our work suggests that …
The expression levels of histamine, beta-hexosaminidase, interleukin-4 and tumor necrosis factor-alpha were decreased by salvinorin
366 results