Salvia
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| 2002 |
| Roth et al. report that salvinorin A is a highly-selective kappa-opioid agonist, solving the long mystery of its site of action. |
| Most of the classical hallucinogens (mescaline, LSD, DMT, etc.) are serotonergic agonists. Salvinorin A is therefore both chemically and pharmacologically distinctive. |
| References Roth BL, Baner K, Westkaemper R, et al. "Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist". Proceedings of the National Academy of Sciences of the United States of America. Sep 3 2002;99(18):11934-9. |
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