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Peyote
Timeline
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c. 3700 BCE
Native Americans in the Rio Grande (Shumla Caves) area collected mescaline containing peyote buttons and manufactured peyote effigy sculptures.    [More Info]

Two dried "peyote buttons", more than 5000 years old, were found in Shumla cave and tested by radio carbon dating and GC/MS. They were found to contain mescaline. Peter Furst mentioned these results in a 1989 publication, and the tests were re-confirmed in 2005 by El-Seedi et al. An article by Terry et al in 2006 reported that these were not actually peyote buttons, but formed artifacts made from peyote and other plants!


References
Terry M, Steelman KL, Guilderson T, Dering P, Rowe MW. “Lower Pecos and Coahuila peyote: new radiocarbon dates”. J Archaelogical Science. 2006;33:1017-1021. El-Seedi HR, Smet PA, Beck O, et al. "Prehistoric peyote use: Alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas". J Ethnopharmacol. 2005;101(1-3):238-42.


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