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Datura
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1676
A group of soldiers in Jamestown, Virginia ingest boiled datura and become delirious for days.   

Robert Beverly wrote of the incident in 1705:

"The James-Town Weed (which resembles the Thorny Apple of Peru, and I take to be the Plant so call'd) is supposed to be one of the greatest Coolers in the World. This being an early Plant, was gather'd very young for a boil'd Salad, by some of the Soldiers sent thither, to pacific the Troubles of Bacon; and some of them eat plentifully of it, the Effect of which was a very pleasant Comedy; for they turn'd natural Fools upon it for several Days: One would blow up a Feather in the Air; another wou'd dart Straws at it with much Fury; and another stark naked was sitting up in a Corner, like a Monkey, grinning and making Mows at them; a Fourth would fondly kiss, and paw his Companions, and snear in their Faces, with a Countenance more antick, than any in a Dutch Droll. In this frantick Condition they were confined, lest they should in their Folly destroy themselves; though it was observed, that all their Actions were full of Innocence and good Nature. Indeed, they were not very cleanly; for they would have wallow'd in their own Excrements, if they had not been prevented. A Thousand such simple Tricks they play'd, and after Eleven Days, return'd to themselves again, not remembring any thing that had pass'd."



References
Beverly R. The History and Present State of Virginia, In Four Parts. 1705. Part II, pg. 24.


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