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Datura
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c. 8th Century
The Buddhist scripture Guhyasamāja Tantra instructs in the ritual use of datura.   

For example, the Tantra states "[M]aking an image of the enemy with the excrement and urine of those who follow the great Dharma, wrathfully burn it in a fire of thorn-wood, and even the Buddha will certainly perish. [...] So he said black mustard-seeds, salt, oil, poison, and thorn-apple [datura], these are taught as the supreme destroyers of all the Buddhas."


References
Fremantle F. A Critical Study of the Guhyasamāja. Doctoral Dissertation, University of London. 1971. p 103.


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